Medications

Novel drug makes mice skinny even on sugary, fatty diet

Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have developed a small-molecule drug that prevents weight gain and adverse liver changes in mice fed a high-sugar, high-fat ...

Diseases, Conditions, Syndromes

Gut molecules may affect fattiness of liver

Sphingolipids—molecules ubiquitous throughout the human body, named after the Egyptian Sphinx for their complexity when scientists discovered them nearly 150 years ago—are not necessarily household conversation topics.

Medical research

Liver fibrosis: The fatal signaling pathway

At least 5 million people in Germany suffer from liver disease. Fibrosis, the pathological proliferation of connective tissue, plays an important role in many complications of chronic liver problems. Activated hepatic stellate ...

Diseases, Conditions, Syndromes

RNA modification may protect against liver disease

A chemical modification that occurs in some RNA molecules as they carry genetic instructions from DNA to cells' protein-making machinery may offer protection against non-alcoholic fatty liver, a condition that results from ...

Diseases, Conditions, Syndromes

Gut microbiome composition could make diarrhea less likely

Antibiotics are known to upset the balance of bacteria in the intestinal tract. In some cases, antibiotics can cause the bacterium Clostridium difficile (C. difficile) to overgrow wildly, causing diarrhea and, in severe cases, ...

Parkinson's & Movement disorders

Faulty cellular membrane 'mix' linked to Parkinson's disease

Working with lab-grown human brain cells, Johns Hopkins researchers report they have uncovered a much sought-after connection between one of the most common genetic mutations in Parkinson's disease and the formation of fatty ...

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