Most neurodegenerative diseases, including dementias, involve proteins aggregating into filaments called amyloids. In most of these diseases, researchers have identified the proteins that aggregate, allowing them to target ...
Dec 6, 2023
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75
Under normal circumstances, tau protein is part of the brain's infrastructure, important for stabilizing neurons into their proper shapes. But sometimes tau gets knotted up into tangles and turns toxic, injuring brain tissue ...
Sep 21, 2023
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Even though neurodegenerative diseases often strike in middle age or later, patients could have structural differences in their brains that arise before birth.
Aug 22, 2023
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New research has discovered that some patients with motor neuron disease (MND) and frontotemporal dementia (FTD) carry the same rare genetic defects that cause other neurodegenerative diseases.
May 9, 2023
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Targeting part of an antiviral pathway triggered by the accumulation of a key pathogen shared in Alzheimer's disease and frontotemporal dementia may one day offer a new therapeutic approach to deterring or delaying cognitive ...
Apr 24, 2023
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44
Scientists have long known that the complement cascade, a set of immune system proteins, protects against infection in the body. But in recent years, researchers have uncovered new roles for the system in the brain, including ...
Mar 30, 2023
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Sometimes in science, "Eureka!" moments happen with surprisingly little effort. Sometimes they take years or decades to emerge. Such was the case with Brian Kraemer's research team and their recent study of the protein tau ...
Feb 6, 2023
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In November, researchers reported the drug lecanemab slowed the progression of Alzheimer's disease. The effect was modest, but it has generated tremendous excitement because it was the first time a drug had been shown to ...
Dec 27, 2022
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107
Zooming in on a single disease and studying it intensely is often the most productive route to finding treatments. But there's no easy way to distinguish among people living with any of the primary tauopathies—a group of ...
Nov 24, 2022
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The clean-up of cellular "protein clumps" could prevent the onset of some types of dementia, according to a new study from The University of Queensland.
Nov 7, 2022
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