Medical research

Researchers develop new database of druggable fusion targets

When sections from two separate genes merge due to various factors, such as translocation or splicing, the hybrid that is formed is called a gene fusion. In recent years, it has been discovered that these fusion events play ...

Oncology & Cancer

Pediatric cancers: Why some forms of leukemia only affect children

Acute myeloid leukemia (AML) mainly affects children, with often poor prognosis despite several decades of research into more effective treatments. A new study explains why some forms of leukemia develop in very young children ...

Diseases, Conditions, Syndromes

Potent antibody curbs Nipah and Hendra virus attack

A new monoclonal antibody has been shown to impede the fusion machinery henipaviruses use to merge with the membrane of cells they are attempting to breach. The antibody halts the attack by blocking membrane fusion and the ...

Oncology & Cancer

Early genome catastrophes can cause non-smoking lung cancer

Catastrophic rearrangements in the genome occurring as early as childhood and adolescence can lead to the development of lung cancer in later years in non-smokers. This finding, published in Cell, helps explain how some non-smoking-related ...

Psychology & Psychiatry

Researchers have identified the first human-specific fusion gene

University at Buffalo researchers have identified the first human-specific fusion gene—a hybrid of two genes—implicated in Alzheimer's disease. The finding suggests that a neurotransmitter receptor, previously successful ...

Oncology & Cancer

CRISPR catches out critical cancer changes

In the first large-scale analysis of cancer gene fusions, which result from the merging of two previously separate genes, researchers at the Wellcome Sanger Institute, EMBL-EBI, Open Targets, GSK and their collaborators have ...

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