Oncology & Cancer
Team finds new genetic anomalies in lung cancer
Developing effective treatments for lung cancer has been challenging, in part because so many genetic mutations play a role in the disease.
Dec 22, 2014
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News tagged with gene fusions
Oncology & Cancer
First and only therapeutic drug for ALK-positive lung cancer approved
In a major triumph for personalized medicine, the FDA approved the drug crizotinib for use with the lung cancer type known as ALK-positive.
Aug 31, 2011
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Oncology & Cancer
Identifying drug target candidates to treat pediatric rhabdomyosarcoma tumors
Cancer biologists are yet to understand the mechanisms and cellular hierarchy leading to the developmental arrest in rhabdomyosarcoma (RMS)—a group of pediatric cancers, which remain enigmatic.
Oncology & Cancer
Fused genes found in esophageal cancer cells offer new clues on disease mechanisms
Despite years of research, cellular mechanisms contributing to cancers like esophageal adenocarcinoma have remained elusive. What has puzzled researchers was how genes in the healthy cells lining the esophagus turned the ...
Aug 26, 2016
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Oncology & Cancer
Study reveals new therapeutic target for aggressive type of rhabdomyosarcoma
To find new treatment approaches for childhood cancer, scientists at St. Jude Children's Research Hospital are digging deep into disease biology to target a process long considered "undruggable." The approach revealed a new ...
Jul 13, 2022
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Oncology & Cancer
Study pinpoints a genetic cause of most lethal brain tumor, may lead to new treatment
Researchers at Columbia University Medical Center (CUMC) have discovered that some cases of glioblastoma, the most common and aggressive form of primary brain cancer, are caused by the fusion of two adjacent genes. The study ...
Jul 26, 2012
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Oncology & Cancer
Half of prostate cancers could potentially benefit from new type of cancer drugs, study finds
About half of prostate cancers have a genetic anomaly that appears to make tumor cells responsive to a new class of cancer-fighting drugs, a new study from the University of Michigan Comprehensive Cancer Center finds.
May 18, 2011
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Genetics
Distinct molecular subtype of prostate cancer identified
A collaborative expedition into the deep genetics of prostate cancer has uncovered a distinct subtype of the disease, one that appears to account for up to 15 percent of all cases, say researchers at Weill Cornell Medical ...
May 20, 2012
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Genetics
Gene fusion in lung cancer afflicting never-smokers may be target for therapy
Smoking is a well-known risk factor for lung cancer, but nearly 25% of all lung cancer patients have never smoked. In a study published online today in Genome Research, researchers have identified a previously unknown gene ...
Dec 22, 2011
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Oncology & Cancer
Early genome catastrophes can cause non-smoking lung cancer
Catastrophic rearrangements in the genome occurring as early as childhood and adolescence can lead to the development of lung cancer in later years in non-smokers. This finding, published in Cell, helps explain how some non-smoking-related ...
May 31, 2019
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