A gene linked to autism spectrum disorders that was manipulated in two lines of transgenic mice produced mature adults with irreversible deficits affecting either learning or social interaction.
Jun 5, 2013
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Researchers at the Monell Center and collaborators have identified a protein that is critical to the ability of mammals to smell. Mice engineered to be lacking the Ggamma13 protein in their olfactory receptors were functionally ...
May 6, 2013
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Sand-dwelling and rock-dwelling cichlids living in East Africa's Lake Malawi share a nearly identical genome, but have very different personalities. The territorial rock-dwellers live in communities where social interactions ...
Apr 26, 2013
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The t haplotype in mice—a block of linked genes occupying the proximal half of mouse chromosome 17—is one of the best-studied examples of a selfish genetic element. Through an elaborate sperm-poisoning system, heterozygous ...
Mar 8, 2013
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Genetics researchers have identified 25 additional copy number variations (CNVs)—missing or duplicated stretches of DNA—that occur in some patients with autism. These CNVs, say the researchers, are "high impact": although ...
Jan 14, 2013
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The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Jan 13, 2013
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(HealthDay)—Meta-analyses have identified an additional 16 loci with genome-wide significance for coronary artery disease (CAD), according to research presented at the annual meeting of the American Society of Human Genetics, ...
Nov 9, 2012
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(Medical Xpress)—An interdisciplinary team of researchers has dissected a case of synergy in drug-resistant chronic myeloid leukemia to understand the mechanism by which two drugs, danusertib and bosutinib, work together ...
Oct 24, 2012
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(Medical Xpress)—European researchers have discovered that five genes play a key role in determining human facial shapes. Presented in the journal PLoS Genetics, the genome-wide association study on facial phenotype can ...
Oct 11, 2012
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(Medical Xpress)—Gaining more insight into predicting how genes affect physical or behavioral traits by charting the genotype-phenotype map holds promise to speed discoveries in personalized medicine. But figuring out exactly ...
Sep 11, 2012
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