Immunology

How the body's B cell academy ensures a diverse immune response

Cells jostling for a spot in a germinal center face a cutthroat admissions process. Formed after exposure to a pathogen or vaccine, germinal centers act as a kind of immune system training academy, helping B cells refine ...

Medical research

When the body's B cell training grounds stay open after hours

If B cells are the munitions factories of the immune system, manufacturing antibodies to neutralize harmful pathogens, then the tiny biological structures known as germinal centers are its weapons-development facilities. ...

Diseases, Conditions, Syndromes

Antibodies improve in quality for months after COVID-19 vaccination

For at least six months after COVID-19 vaccination, antibodies produced by immune cells become steadily more formidable and more precisely targeted against the virus that causes COVID-19, according to a study of the antibody ...

Diseases, Conditions, Syndromes

What makes an mRNA vaccine so effective against severe COVID-19?

The first two vaccines created with mRNA vaccine technology—the Pfizer/BioNTech and Moderna COVID-19 vaccines—are arguably two of the most effective COVID vaccines developed to date. In clinical trials, both were more ...

Immunology

Antibody-producing b cells may be 'predestined' for their fates

The master regulator behind the development of antibody-producing cells has been identified in a study by investigators at Weill Cornell Medicine. The findings provide new insight into the inner workings of the immune system ...

Medical research

Putting the brakes on immune reactions

When we are exposed to a pathogen, the immune system's B cells swarm to our lymph nodes, spleens, and tonsils. There, those cells mutate in germinal centers—microscopic boot camps that rush the B cells through volleys of ...

Immunology

How the immune system deals with the gut's plethora of microbes

The gut is an unusually noisy place, where hundreds of species of bacteria live alongside whatever microbes happen to have hitched a ride in on your lunch. Scientists have long suspected that the gut's immune system, in the ...

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