Researchers at Baylor College of Medicine have investigated the effect of infection with COVID-19 on the levels of oxidative stress, oxidant damage and glutathione, the most abundant physiological antioxidant. Compared to ...
Dec 27, 2021
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A randomized, double blind human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC—a combination of glycine and N-acetylcysteine—improves many age-associated ...
Aug 18, 2022
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In a series of recently published studies using animals and people, Johns Hopkins Medicine researchers say they have further characterized a set of chemical imbalances in the brains of people with schizophrenia related to ...
May 8, 2019
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Chalk up another reason why your gut bacteria are so critical to your health—and why these microorganisms could be the key to preventing a host of diseases. Scientists in Sweden have discovered that human intestinal flora ...
Oct 19, 2015
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Australian researchers have shown that a dietary supplement that increases the levels of a powerful antioxidant in the brain may represent a novel strategy for the treatment and/or prevention of cognitive impairment and debilitating ...
Feb 17, 2021
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Researchers at Oregon State University have found that a specific detoxification compound, glutathione, helps resist the toxic stresses of everyday life - but its levels decline with age and this sets the stage for a wide ...
Oct 24, 2016
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Premature aging in people with HIV is now recognized as a new, significant public health challenge. Accumulating evidence shows that people with HIV who are between 45 to 60 years old develop characteristics typically observed ...
Oct 15, 2020
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(Medical Xpress)—When something bad happens to otherwise healthy neurons it's easy to blame the usual suspects—the mitochondria. In some cases the nucleus might be the one at fault, as in a de novo mutation in a critical ...
Mushrooms may contain unusually high amounts of two antioxidants that some scientists suggest could help fight aging and bolster health, according to a team of Penn State researchers.
Nov 9, 2017
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All human tumors originating from various tissues share a series of properties that define them, including the ability to prevent cell death. Instead, healthy organs induce programmed cell death or apoptosis to balance their ...
Aug 1, 2022
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Glutathione (GSH) is a tripeptide that contains an unusual peptide linkage between the amine group of cysteine (which is attached by normal peptide linkage to a glycine) and the carboxyl group of the glutamate side-chain. It is an antioxidant, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides.
Thiol groups are reducing agents, existing at a concentration of approximately 5 mM in animal cells. Glutathione reduces disulfide bonds formed within cytoplasmic proteins to cysteines by serving as an electron donor. In the process, glutathione is converted to its oxidized form glutathione disulfide (GSSG), also called L(-)-Glutathione.
Once oxidized, glutathione can be reduced back by glutathione reductase, using NADPH as an electron donor. The ratio of reduced glutathione to oxidized glutathione within cells is often used as a measure of cellular toxicity.
This text uses material from Wikipedia, licensed under CC BY-SA
