In chronic hepatitis B, the liver contains immune cells that could destroy hepatitis B virus infected cells but are inactive. A team from the Technical University of Munich (TUM) has discovered that cells in blood vessels ...
Jul 10, 2024
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Hepatocellular carcinoma (HCC) represents a significant global health burden as one of the most common malignancies in individuals with chronic liver disease or cirrhosis. This malignancy evolves through a multistep process, ...
May 24, 2024
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In mammals, the liver detects the body's energy demand at any given moment and mobilizes nutrient reserves to meet it. It is a vital function that is subdivided into multiple tasks: from releasing glucose into the blood when ...
Mar 18, 2024
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A research group from the Graduate School of Medicine and Research Institute of Environmental Medicine at Nagoya University report that cholesterol accumulation in macrophages promotes liver fibrosis in the development of ...
Sep 19, 2023
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A new study reports the findings of the functional evaluation of six AAV vectors in 12 preclinical models of the human liver. The study, which aimed to uncover which combination of models is the most relevant for the identification ...
May 2, 2023
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Liver cancer is the third leading cause of cancer death and the sixth most common cancer type worldwide. Major risk factors include environmental and metabolic stressors, such as obesity, viral hepatitis and steatohepatitis ...
Apr 12, 2023
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SARS-CoV-2 infects and causes damage to multiple organs in COVID-19 patients. In particular, liver damage has been associated with COVID-19 severity. However, an understanding of the liver pathophysiology of these patients ...
Mar 8, 2023
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A gene expression-based screening assay using chimeric mice with humanized hepatocytes revealed that letrozole has a modifying effect on fibrosis-related gene expression in the hepatocytes, including YAP, CTGF, TGF-β, and ...
Nov 8, 2022
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Almost all liver cancers develop after decades of chronic liver disease, but a new discovery by Columbia researchers may lead to treatments that could break the link.
Oct 21, 2022
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A study led by Texas A&M AgriLife Research provides compelling evidence of the important role of hepatocyte adenosine kinase in the progression of nonalcoholic fatty liver disease (NAFLD). The study, "Hepatocyte Adenosine ...
Oct 5, 2022
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