A large team of researchers affiliated with several institutions in the U.S. and one in Germany has found evidence that makes a case for a dominant-negative effect with TP53 mutations. In their paper published in the journal ...
Ribosomes are essential for life, generating all of the proteins required for cells to grow. Mutations in some of the proteins that make ribosomes cause disorders characterized by bone marrow failure and anemia early in life, ...
Mar 31, 2014
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(Medical Xpress)—A study dating the age of more than 1 million single-letter variations in the human DNA code reveals that most of these mutations are of recent origin, evolutionarily speaking. These kinds of mutations ...
Nov 28, 2012
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A team at CSHL for the 1st time reveals the birth timing and embryonic origin of a critical class of inhibitory brain cells called chandelier cells, tracing the specific paths they take during early development into the cerebral ...
Nov 22, 2012
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Human intelligence and behavior require optimal functioning of a large number of genes, which requires enormous evolutionary pressures to maintain. A provocative hypothesis published in a recent set of Science and Society ...
Nov 12, 2012
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(Medical Xpress)—Researchers from the US and Japan have shown that an aggressive type of brain tumor can arise from normal cells in the central nervous system such as neurons. The cells revert to an earlier, undifferentiated ...
One subtype of breast cancer shares many genetic features with high-grade serous ovarian cancer, a cancer that is very difficult to treat, according to researchers supported by the National Institutes of Health. The findings ...
Sep 23, 2012
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(Medical Xpress) -- As the Earth's human population has skyrocketed since the rise of agriculture some 10,000 years ago -- to 7 billion people from a few million -- so, too, has the number of rare genetic variants.
May 11, 2012
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Researchers at the University of California, San Diego School of Medicine say that losing the ability to make a particular kind of sugar molecule boosted disease protection in early hominids, and may have directed the evolutionary ...
Oct 10, 2011
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Research by Victor Ambros, Ph.D., provides new insights into a recently identified class of neurodevelopmental disorders called Argonaute syndromes. Dr. Ambros and colleagues believe their Proceedings of the National Academy ...
Mar 25, 2024
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