Medications
Circadian rhythms can influence drugs' effectiveness
Giving drugs at different times of day could significantly affect how they are metabolized in the liver, according to a new study from MIT.
11 hours ago
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News tagged with human liver cells
Genetics
Team performs the first gene therapy tests in a whole human liver
In a worldwide first-of-its-kind study published in the journal Nature Communications this week, a team of scientists from Children's Medical Research Institute (CMRI) have tested novel gene therapies in a whole human liver, ...
Mar 14, 2024
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Endocrinology & Metabolism
Mice study suggests metabolic diseases may be driven by gut microbiome, loss of ovarian hormones
The gut microbiome interacts with the loss of female sex hormones to exacerbate metabolic disease, including weight gain, fat in the liver and the expression of genes linked with inflammation, researchers found in a new rodent ...
Feb 22, 2024
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Oncology & Cancer
Chronic jet lag leads to human liver cancer in a mouse model
When asked about what could cause cancer, people most likely think of chemicals like tobacco or radiation such as UV light in sunshine, but chronic jet lag probably does not come to mind. Human epidemiological studies have ...
Feb 7, 2024
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Oncology & Cancer
Researchers develop a robust platform to generate cells to enhance cancer immunotherapy efficacy
A joint research team has used stem cells to generate human immune cells for application in cancer immunotherapy. By replicating the natural process through which our bodies generate immune cells, this breakthrough platform ...
Feb 6, 2024
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Gastroenterology
New 3D bioprinted model to study common liver disease, find effective treatment
Metabolic dysfunction-associated steatohepatitis, or MASH, is an inflammatory, liver-scarring disease that has reached epidemic proportions, with an estimated 1.5% to 6.5% of U.S. adults afflicted by the condition, and roughly ...
Jan 23, 2024
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Medical research
Researchers identify a potential target for reversing poor metabolic traits
During oxidative stress, excess production of reactive oxygen species causes cell and tissue damage.
Dec 21, 2023
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Medical research
Microbiome insights found in poop help predict infections in liver transplant patients
In a new study, researchers at the University of Chicago were able to predict postoperative infections in liver transplant patients by analyzing molecules in their poop. Their analysis represents a key leap forward in exploring ...
Dec 16, 2023
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Genetics
Acetaldehyde dehydrogenases in liver zonation and liver cancer
A study, published in the journal Gene Expression and led by Brady Jin-Smith from the Department of Pathology at Tulane University, focuses on ALDHs, a group of key enzymes that catalyze the irreversible oxidation of various ...
Dec 15, 2023
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Gastroenterology
New hope for patients with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a major health problem affecting approximately 30% of people in Western countries and which has been in sharp increase over the last three decades.
Dec 5, 2023
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