The earliest eye damage from prion disease takes place in the cone photoreceptor cells, specifically in the cilia and the ribbon synapses, according to a new study of prion protein accumulation in the eye by National Institutes ...
Jan 29, 2021
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An article published in the journal PLOS Pathogens reports a realistic computational model for the structure and mechanism of replication of prions, infectious agents responsible for mad cow disease and other neurodegenerative ...
Jul 11, 2019
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Approximately two years after establishing a human cerebral organoid system to study Creutzfeldt-Jakob disease (CJD), National Institutes of Health researchers have further developed the model to screen drugs for potential ...
Mar 9, 2021
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In a recent publication, researchers of the Computational Biology group at the Luxembourg Centre for Systems Biomedicine showed that neuro-inflammation plays a crucial role in initiating prion disease.
Nov 29, 2012
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National Institutes of Health scientists studying the progression of inherited and infectious eye diseases that can cause blindness have found that microglia, a type of nervous system cell suspected to cause retinal damage, ...
Mar 27, 2019
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A team of researchers from Case Western Reserve University School of Medicine have identified a mechanism that can prevent the normal prion protein from changing its molecular shape into the abnormal form responsible for ...
Jul 18, 2013
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Prion diseases—incurable, ultimately fatal, transmissible neurodegenerative disorders of mammals—are believed to develop undetected in the brain over several years from infectious prion protein. In a new study, National ...
Sep 22, 2015
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Many changes take place in the brain long before symptoms appear. This has been shown in mice in two studies of prion diseases in which the brain gradually deteriorates. The results suggest that changes can be studied extremely ...
Oct 10, 2022
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Bovine spongiform encephalopathy (BSE, or "mad cow disease") is a fatal disease in cattle that causes portions of the brain to turn sponge-like. This transmissible disease is caused by the propagation of a misfolded form ...
Jul 9, 2012
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Familial human prion diseases are passed within families and are associated with 34 known prion protein mutations. To determine whether three of the unstudied mutations are transmissible, scientists from the National Institute ...
Mar 8, 2018
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