An article published in the journal PLOS Pathogens reports a realistic computational model for the structure and mechanism of replication of prions, infectious agents responsible for mad cow disease and other neurodegenerative ...
Jul 11, 2019
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National Institutes of Health scientists studying the progression of inherited and infectious eye diseases that can cause blindness have found that microglia, a type of nervous system cell suspected to cause retinal damage, ...
Mar 27, 2019
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Familial human prion diseases are passed within families and are associated with 34 known prion protein mutations. To determine whether three of the unstudied mutations are transmissible, scientists from the National Institute ...
Mar 8, 2018
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A new model of fatal brain diseases is being developed in the fruit fly by a team led by Dr Raymond Bujdoso at the University of Cambridge, and could lead to a low cost, fast and efficient blood test to diagnose - and prevent ...
Oct 13, 2016
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Prion diseases—incurable, ultimately fatal, transmissible neurodegenerative disorders of mammals—are believed to develop undetected in the brain over several years from infectious prion protein. In a new study, National ...
Sep 22, 2015
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Diagnosis of deadly brain conditions could be helped by new research that shows how infectious proteins that cause the disease spread.
Aug 4, 2015
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In the most systematic and rigorous study conducted thus far in its field, the prion protein (PrPC) was clearly shown to play a role in preventing the onset of epileptic seizures. PrPC is perhaps best known in its 'degenerate' ...
Jul 9, 2015
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Prions are fascinating, enigmatic, and might teach us not only about rare prion diseases like Creutzfeld-Jakob disease, mad cow disease, or scrapie, but also about other more common neurodgenerative diseases. Two studies ...
Jul 2, 2015
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A team of researchers from Case Western Reserve University School of Medicine have identified a mechanism that can prevent the normal prion protein from changing its molecular shape into the abnormal form responsible for ...
Jul 18, 2013
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In a recent publication, researchers of the Computational Biology group at the Luxembourg Centre for Systems Biomedicine showed that neuro-inflammation plays a crucial role in initiating prion disease.
Nov 29, 2012
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