Mutations in the SCN3A gene cause a spectrum of neurological conditions collectively referred to as SCN3A-related neurodevelopmental disorders, which includes different types of epilepsy and brain malformations.
Nov 21, 2023
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More than 37 million people in the U.S. have diabetes. According to the American Diabetes Association, 8.4 million Americans needed to take insulin in 2022 to lower their blood sugar. Insulin, however, is tricky to deliver ...
Nov 15, 2023
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A new study by University of Iowa researchers finds that rare lung cells known as pulmonary ionocytes facilitate the absorption of water and salt from the airway surface. This function is exactly the opposite of what was ...
Oct 23, 2023
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Losing the activity of a key ion channel in the brain may contribute to the buildup of a devastating and toxic protein responsible for the clumps of plaque that accumulate in Alzheimer's disease, a team of neurobiologists ...
More cases of children born with abnormal brain development may have genetic explanations than previously thought, according to a recent study published in JAMA Neurology.
Aug 17, 2023
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The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of full-strength signals between neurons, ...
Aug 16, 2023
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The first mapping of the heart's crucial ion channels reveals a surprisingly extensive network of proteins. This understanding is the first step towards more precise treatment for patients with cardiac arrhythmias.
Aug 16, 2023
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Researchers have identified two ion channel switches that regulate the release of dopamine in the brain, a first step that might one day lead to therapeutics for a wide range of diseases and disorders that currently have ...
Aug 12, 2023
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A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.
Aug 3, 2023
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Researchers at NYU College of Dentistry's Pain Research Center have developed a gene therapy that treats chronic pain by indirectly regulating a specific sodium ion channel, according to a new study published in the Proceedings ...
Jul 27, 2023
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Ion channels are pore-forming proteins that help establish and control the small voltage gradient across the plasma membrane of all living cells (see cell potential) by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells. The study of ion channels is known as channelomics and involves many scientific techniques such as voltage clamp electrophysiology (in particular patch clamp), immunohistochemistry, and RT-PCR.
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