Medical research

Discovery could improve cystic fibrosis treatment

Researchers exploring the effects of a long-standing treatment for cystic fibrosis have discovered a potential new target for drugs to treat the disease, which has no cure and typically cuts decades off the lives of patients.

Diseases, Conditions, Syndromes

Discovery of novel mechanisms that cause migraines

Researchers at CNRS, Université Côte d'Azur and Inserm have demonstrated a new mechanism related to the onset of migraine. They found how a mutation that causes dysfunction in a protein which inhibits neuronal electrical ...

Neuroscience

Adding new channels to the brain remote control

By enabling super-fast remote control of specific cells, light-activated proteins allow researchers to study the function of individual neurons within a large network—even an entire brain. Now one of the pioneers of 'optogenetics' ...

Alzheimer's disease & dementia

New biomarker for Alzheimer's disease found via CRISPR technique

The objective of the research, undertaken in the laboratories of the IBPM, is to develop a model for studying Alzheimer's disease (AD) of sporadic origin—in other words, AD that is not due to a hereditary genetic mutation. ...

Neuroscience

Research discovers new channel-gating mechanism

Computational biophysicists are not used to making discoveries, says Jianhan Chen at the University of Massachusetts Amherst, so when he and colleagues cracked the secret of how cells regulate Big Potassium (BK) channels, ...

Neuroscience

Scientists turn unexpected brain study results into research tool

Puzzled by their experimental results, a team of scientists from Baylor College of Medicine and Texas Children's Hospital investigated why a research tool that was expected to suppress neuronal activity actually was stimulating ...

Neuroscience

Research identifies possible new pathway to treat anxiety

Researchers know that anxiety is a result of repeated stress. William Colmers, a University of Alberta professor in the Department of Pharmacology, is trying to understand why stress affects people differently, and to identify ...

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Ion channel

Ion channels are pore-forming proteins that help establish and control the small voltage gradient across the plasma membrane of all living cells (see cell potential) by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells. The study of ion channels is known as channelomics and involves many scientific techniques such as voltage clamp electrophysiology (in particular patch clamp), immunohistochemistry, and RT-PCR.

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