Immunology

Gut immunity more developed before birth than previously thought

Most biology textbooks explain that the fetal immune system is largely undeveloped and that it learns after being exposed to the world at birth. New research from the University of Pittsburgh School of Medicine and UPMC Children's ...

Diseases, Conditions, Syndromes

People's initial immune response to dengue fever analyzed

Researchers have come one step closer to understanding how the immune system responds to acute dengue fever, a disease that has affected hundreds of thousands of people in Southeast Asia this summer alone. In a study published ...

Medications

PET imaging shows if PD-1 cancer immunotherapy is working

PD-1 is a protein on our T cells that normally keeps these immune cells from running amok. A growing number of cancer drugs are designed to inhibit PD-1, enabling patients' T-cells to attack and kill cancerous cells. PD-1 ...

Oncology & Cancer

Genome screen uncovers new targets for cancer immunotherapy

Immunotherapy has revolutionized the treatment of cancer in the last decade, yet many tumors do not respond to these new therapies. A new genome-wide screen of 20,000 human genes in T cells have turned up several new candidates ...

Medical research

Killer cells the key to potentially life‑saving cancer vaccines

"I'll be honest, when I first started working on this I didn't fully accept it." That's Dr. Andrew Makrigiannis, head of the Department of Microbiology & Immunology, discussing his groundbreaking research on natural killer ...

Oncology & Cancer

Making cancer stem cells visible to the immune system

Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for killer cells. This protective mechanism can be tricked with drugs. In the journal Nature, scientists from Basel, Tübingen ...

Diseases, Conditions, Syndromes

Taking the 'killer' out of natural killer cells

The virus responsible for chickenpox and shingles employs a powerful strategy of immune evasion, inhibiting the ability of natural killer cells to destroy infected cells and produce molecules that help control viral infection, ...

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