In a multi-center phase 1 and 2 trial (BRUIN, NCT03740529), researchers from leading cancer centers across the globe, including the Medical College of Wisconsin (MCW) in Milwaukee, tested Bruton tyrosine kinase inhibitor ...
Jun 2, 2023
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Scientists at Duke-NUS Medical School, A*STAR's Genome Institute of Singapore (GIS), Singapore General Hospital (SGH) and their colleagues in Singapore have used artificial intelligence (AI) to accelerate the discovery of ...
Jun 1, 2023
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Brepocitinib is an oral drug that inhibits certain enzymes involved in inflammation—called tyrosine kinase 2 and Janus kinase 1—and is being tested for the treatment of several immunological diseases. A phase IIb randomized ...
May 17, 2023
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When it comes to cancer, developing resistance to therapy and metastasis, the ability to spread outside the organ of origin, are issues of major concern as they give cancer the upper hand.
May 17, 2023
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For centuries, scientists have tried to crack the mystery of a devastating ailment once called "the shaking palsy." But Parkinson's disease, which causes tremors, muscle stiffness and difficulty walking, remains the second ...
Apr 21, 2023
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Northwestern Medicine scientists have identified an enzyme which aids tumors in evading the immune system, findings that could provide future directions for tumor treatment, according to a study published in Nature Communications.
Apr 12, 2023
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A recent study from Texas Children's Hospital and Baylor College of Medicine has expanded the clinical spectrum of a new epileptic disorder called Intellectual Developmental Disorder with Macrocephaly, Seizures, and Speech ...
Mar 29, 2023
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Tyrosine kinase inhibitors are a type of targeted cancer medicine that can attack specific types of cancer cells and prevent them from multiplying. Although these inhibitors, called TKIs, can be very useful in fighting certain ...
Mar 17, 2023
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The latest research from SAHMRI and the University of Adelaide has discovered a potential new therapy for chronic myeloid leukemia (CML) patients who've achieved excellent results from current treatment and are hoping to ...
Mar 1, 2023
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Cancer biologists are yet to understand the mechanisms and cellular hierarchy leading to the developmental arrest in rhabdomyosarcoma (RMS)—a group of pediatric cancers, which remain enigmatic.
In chemistry and biochemistry, a kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates, a process referred to as phosphorylation. Kinases are part of the larger family of phosphotransferases. Kinases are not to be confused with phosphorylases, which carry out phosphorolysis, the breaking of a bond using an inorganic phosphate group; or with phosphatases, which remove phosphate groups.
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