The formation of amyloid plaques in the brain is a hallmark of Alzheimer's disease. But drugs designed to reduce accumulations of these plaques have so far yielded, at best, mixed results in clinical trials.
Dec 1, 2022
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142
Dementia encompasses a range of neurodegenerative conditions that lead to memory loss and cognitive deficiencies and affect some 55 million people worldwide. Yet despite its prevalence, there are few effective treatments, ...
Oct 27, 2022
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121
Aggregates of the protein alpha-synuclein spread in the brains of people with Parkinson's disease through a cellular waste-ejection process, suggests a new study led by Weill Cornell Medicine researchers.
Sep 20, 2022
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60
Scientists at the Icahn School of Medicine at Mount Sinai in New York, the National Center for Advancing Translational Sciences (NCATS), and elsewhere have reversed the effects of several life-threatening inherited neurodegenerative ...
Sep 8, 2022
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A new combination of drugs could fix the broken lysosomal enzyme pathway in Parkinson's disease-afflicted brain cells, according to a Northwestern Medicine study published in Neuron.
Nov 24, 2021
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Adding to the growing body of literature demonstrating the feasibility of correcting lethal genetic diseases before birth, researchers at Children's Hospital of Philadelphia (CHOP) have used DNA base editing in a prenatal ...
Jul 13, 2021
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A rare and controversial mutation in the phospholipase D3 (PLD3) protein—previously linked to Alzheimer's disease—interferes with PLD3's vital recycling function inside neurons. Matthew Schrag of Vanderbilt University ...
Apr 8, 2021
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49
Cancer starts with mutations in a cell's DNA, but new UC San Francisco research shows that the endurance of a tumor relies on its ability to rapidly evolve and adapt to challenges brought about by the environment in which ...
Apr 2, 2021
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56
A versatile probe that can detect with pinpoint accuracy the programmed destruction of defective mitochondria—the powerhouses of cells—has been developed by RIKEN researchers. They used it to show that damaged mitochondria ...
Aug 14, 2020
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128
Studying mice, scientists have shown that boosting the activity of specific immune cells in the heart after a heart attack can protect against developing heart failure, an invariably fatal condition. Patients with heart failure ...
Nov 6, 2019
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