Diseases, Conditions, Syndromes

Why are some COVID-19 infected people asymptomatic?

Researchers worldwide have been surprised to see that individuals can be infected with the SARS-CoV-2 virus—the virus that produces COVID-19—without showing symptoms. Since these individuals expose others to infection ...

Oncology & Cancer

'Backpacks' boost immune cells' ability to kill cancer

Macrophages are immune cells that patrol the body looking for potential threats like viruses, bacteria, and cancer cells, and engulf and destroy them. However, cancerous tumors have a nasty trick up their sleeves: they secrete ...

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Macrophage

Macrophages (Greek: big eaters, from makros "large" + phagein "eat"; abbr. ) are white blood cells within tissues, produced by the division of monocytes. Human macrophages are about 21 micrometres in diameter. Monocytes and macrophages are phagocytes, acting in both non-specific defense (or innate immunity) as well as to help initiate specific defense mechanisms (or adaptive immunity) of vertebrate animals. Their role is to phagocytose (engulf and then digest) cellular debris and pathogens either as stationary or as mobile cells, and to stimulate lymphocytes and other immune cells to respond to the pathogen. They can be identified by specific expression of a number of proteins including CD14, CD11b, F4/80 (mice)/EMR1 (human), Lysozyme M, MAC-1/MAC-3 and CD68 by flow cytometry or immunohistochemical staining. They move by action of Amoeboid movement.

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