Immunology

Identification of new populations of immune cells in the lungs

Due to their function, the lungs are constantly exposed to various compounds carried in the air, sometimes harmful, sometimes harmless. The lung immune system plays a pivotal role in deciding or not deciding to mount an immune ...

Oncology & Cancer

Researchers discover a new form of immunotherapy

A new form of immunotherapy that has so far been tested on mice makes it probable that oncologists in the future may be able to treat some of the patients who are not responding to existing types of immunotherapy. Instead ...

Medical research

Tumor macrophage marker offers unique target for treatment

Macrophages are white blood cells that accumulate in tumors, where they aid cancer progression. Now scientists have identified a surface protein found only on the macrophages residing in tumors, exposing a target for precise ...

Medical research

Boosting the anti-inflammatory action of the immune system

Researchers at the University of Illinois at Chicago have identified a molecular switch that causes immune cells called macrophages to clean up cellular debris caused by infections instead of contributing to inflammation ...

Oncology & Cancer

Researchers describe a new resistance mechanism

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the ProCure Program of the Catalan Institute of Oncology (ICO) published today inCancer Research a study describing a new mechanism in cancer that turns ...

Medical research

Target found to arrest cancer growth

Adelaide researchers are homing in on a new treatment target for the aggressive blood cancer multiple myeloma.

Oncology & Cancer

Scientists track brain tumor turncoats with advanced imaging

Glioblastomas, the deadliest type of brain tumor in adults, attract "turncoats." These are macrophages, a type of immune cell, which promote tumor progression and mask tumors from the immune system's scrutiny. To better understand ...

Immunology

How bacteria kill host cells from the inside

A bacterial pathogen that typically multiplies outside of host cells can enter and induce the destruction of cells called macrophages, according to a study published June 20 in the open-access journal PLOS Pathogens by Anne-BĂ©atrice ...

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Macrophage

Macrophages (Greek: big eaters, from makros "large" + phagein "eat"; abbr. ) are white blood cells within tissues, produced by the division of monocytes. Human macrophages are about 21 micrometres in diameter. Monocytes and macrophages are phagocytes, acting in both non-specific defense (or innate immunity) as well as to help initiate specific defense mechanisms (or adaptive immunity) of vertebrate animals. Their role is to phagocytose (engulf and then digest) cellular debris and pathogens either as stationary or as mobile cells, and to stimulate lymphocytes and other immune cells to respond to the pathogen. They can be identified by specific expression of a number of proteins including CD14, CD11b, F4/80 (mice)/EMR1 (human), Lysozyme M, MAC-1/MAC-3 and CD68 by flow cytometry or immunohistochemical staining. They move by action of Amoeboid movement.

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