Cardiology

Cardiovascular risk up with metabolic syndrome in psoriasis

(HealthDay)—Metabolic syndrome (MetSyn) is prevalent among patients with psoriasis and is associated with increased cardiovascular risk, according to a study published online Dec. 28 in the Journal of the American Academy ...

Health

Health of fathers-to-be is linked to risk of pregnancy loss

More than a quarter of pregnancies might be ectopic or end in miscarriage or stillbirth if the father-to-be is unhealthy and has three or more medical conditions such as obesity, diabetes, high blood pressure or high cholesterol ...

Diabetes

How poor oral hygiene may result in metabolic syndrome

Periodontal or gum disease is known to be a significant risk factor of metabolic syndrome, a group of conditions increasing the risk for heart disease and diabetes. In a new study, researchers from Tokyo Medical and Dental ...

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Inborn error of metabolism

Inborn errors of metabolism comprise a large class of genetic diseases involving disorders of metabolism. The majority are due to defects of single genes that code for enzymes that facilitate conversion of various substances (substrates) into others (products). In most of the disorders, problems arise due to accumulation of substances which are toxic or interfere with normal function, or to the effects of reduced ability to synthesize essential compounds. Inborn errors of metabolism are now often referred to as congenital metabolic diseases or inherited metabolic diseases, and these terms are considered synonymous.

The term inborn error of metabolism was coined by a British physician, Archibald Garrod (1857-1936), in the early 20th century (1908). He is known for work that prefigured the "one gene, one enzyme" hypothesis, based on his studies on the nature and inheritance of alkaptonuria. His seminal text, Inborn Errors of Metabolism was published in 1923.

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