Genetics

New inherited neurometabolic disorder discovered

Researchers at the Swedish medical university Karolinska Institutet have discovered a new inherited disorder that causes severe mental retardation and liver dysfunction. The disease, adenosine kinase deficiency, is caused ...

Gerontology & Geriatrics

'Beige fat' could hold key to age-related metabolism change

New research suggests a strategy to ward off age-related weight gain, which could prevent obesity and associated health disorders like type 2 diabetes, heart disease and chronic inflammation.

Oncology & Cancer

Metabolic reprogramming of tumor-associated macrophages

Cancer is a complex disease and although billions of dollars have been spent on finding safe and effective therapeutics for it, there is still scope for significant development. Researchers have targeted a variety of biological ...

Genetics

Lifestyle influences metabolism via DNA methylation

An unhealthy lifestyle leaves traces in the DNA. These may have specific effects on metabolism, causing organ damage or disease. Scientists of Helmholtz Zentrum München have now identified 28 DNA alterations associated with ...

Medical research

Molecular corkscrew

Scientists from the universities of Zurich and Duisburg-Essen have discovered a specific function of the protein p97/VCP. They demonstrate that the protein repairs DNA breaks like a corkscrew, a repair mechanism that could ...

Medical research

Researchers examine metabolism in defective cells

University of Alberta researchers are taking a closer look at how two metabolic pathways interact to increase the lifespan of cells with mitochondrial defects. Magnus Friis is the lead author of the study, which was published ...

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