Genetics

Study identifies two genes linked to microcephaly

Northwestern Medicine scientists have identified disease-causing DNA variants in two genes linked to neurodevelopmental deficits including microcephaly in children, according to findings published in Nature Communications.

Genetics

New genes with mutations for developmental disorders identified

The causes of intelligence impairment or epilepsy remain unexplained in more than 50% of cases. Together with international colleagues, researchers at Leipzig University Hospital have discovered two genes with mutations that ...

Medical research

Slowed cell division causes microcephaly

The birth of a human being requires billions of cell divisions to go from a fertilized egg to a baby. At each of these divisions, the genetic material of the mother cell duplicates itself to be equally distributed between ...

Neuroscience

How to generate a brain of correct size and composition

To build the neocortex, a brain area involved in higher cognitive functions, stem cells produce billions of neurons of various types. In a Science study, neuroscientists from Switzerland, Belgium, and the Institute of Science ...

Diseases, Conditions, Syndromes

New insights into how the Zika virus causes microcephaly

A study published today in Science shows that the Zika virus hijacks a human protein called Musashi-1 (MSI1) to allow it to replicate in, and kill, neural stem cells. Almost all MSI1 protein in the developing embryo is produced ...

Genetics

A key gene for brain development

(Medical Xpress)—Neurobiologists at the Research institute of Molecular Pathology (IMP) in Vienna have discovered one of the key genes required to make a brain. Mutations in this gene, called TUBB5, cause neurodevelopmental ...

Medical research

A dimmer switch for human brain cell growth

Controlling how cells grow is fundamental to ensuring proper brain development and stopping aggressive brain tumors. The network of molecules that control brain cell growth is thought to be complex and vast, but now McGill ...

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