Colorectal cancer (CRC) presents with varying clinical characteristics due to tumor heterogeneity. Microsatellite instability (MSI), present in 10–15% of CRC cases, indicates a different clinical trajectory than microsatellite ...
Dec 15, 2023
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In a study published today in Nature Communications, a team of scientists from French-American techbio Owkin and pathology labs in France present a blind validation of MSIntuit CRC, a first-in-class AI-driven digital pathology ...
Nov 7, 2023
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Genomic profiling of patients who were treated for colorectal cancer at a major U.S. cancer center showed that patients with African ancestry had fewer actionable mutations than patients with European ancestry and were less ...
Apr 17, 2023
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The immense progress in the field of therapy options over the past years has significantly improved the chances of cure for patients with colon cancer. However, these new approaches, such as immunotherapies, require precise ...
Feb 14, 2023
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Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol known as MultiMMR that can identify the presence and cause of mismatch repair (MMR) deficiency in a single test from a small sample of ...
Jan 21, 2021
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Systemic sclerosis is an autoimmune disorder that is characterized by excess deposition of connective tissue in the skin, lungs, kidneys and vessels, resulting in lung, heart and kidney dysfunction. In a new study, researchers ...
Jul 31, 2020
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A large international trial involving UCL and University College London Hospitals NHS Foundation Trust (UCLH) has found that pembrolizumab, a form of immunotherapy, more than doubled the 'progression free survival' time of ...
May 29, 2020
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A study at The University of Texas MD Anderson Cancer Center discovered a novel therapeutic vulnerability for patients who have tumors caused by a genetic misfire in the DNA mismatch repair (MMR) pathway, a system for repairing ...
Feb 27, 2020
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The referenced article describes an assay that has a clinically relevant five-day turnaround time and can be conducted on as little as 20 ng genomic DNA with a batch size of up to forty samples in a single run.
Oct 18, 2019
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A new liquid biopsy test could detect microsatellite instability (MSI) and tumor mutational burden (TMB), indicating that it could help determine which patients are likely to respond to immune checkpoint inhibitors, according ...
Sep 11, 2019
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