Immunotherapy with the anti-PD-L1 monoclonal antibody durvalumab improved progression-free survival (PFS) in patients with newly diagnosed advanced or recurrent endometrial cancer compared with chemotherapy alone, with further ...
Oct 23, 2023
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Immunotherapy, a biotherapy that boosts the ability of the immune system to recognize and attack mutant tumor cells, has transformed the treatment landscape for patients battling cancer, which emerges from the progressive ...
Oct 27, 2022
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Scientists from The University of Manchester have shown that testing for two gene families linked to a lifetime epithelial ovarian cancer risk of between 5% and 20% has a much higher than expected detection rate.
Oct 4, 2022
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The quantitative segmentation algorithm (QuantCRC) may improve the prediction of prognosis in colorectal cancer (CRC), according to a study published online Aug. 16 in Gastroenterology.
Sep 12, 2022
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Pathogenic variants in BRCA1/2 genes are associated with an increased risk of breast and ovarian cancer in adults, and variants in mismatch repair (MMR) genes increase the risk of gastrointestinal and other cancers. Until ...
Aug 24, 2022
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A study at The University of Texas MD Anderson Cancer Center discovered a novel therapeutic vulnerability for patients who have tumors caused by a genetic misfire in the DNA mismatch repair (MMR) pathway, a system for repairing ...
Feb 27, 2020
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Researchers have identified a protein critical for the survival of a particular type of tumor cell, according to a study published today in eLife.
Mar 26, 2019
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Pre-operative treatment with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab achieves major pathological responses in 100 percent of early-stage colon cancers with mismatch repair deficiencies, ...
Oct 22, 2018
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Researchers at the European Bioinformatics Institute (EMBL-EBI), the University of Dundee and the Wellcome Sanger Institute have used human and worm data to explore the mutational causes of cancer. Their study, published ...
May 1, 2018
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(HealthDay)—Fewer than half of younger adults with colorectal cancer (CRC) undergo mismatch repair (MMR) deficiency of DNA testing, according to a study published online Nov. 9 in JAMA Oncology.
Nov 13, 2017
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