Genetics

New mutations accumulate in reproductive cells of older mice

Older mice have more new mutations—changes in DNA sequence that occur in the individual rather than being inherited from a parent—than younger mice in the genomes of their mitochondria, according to researchers at Penn ...

Genetics

Researchers uncover the genomics of health

Most diseases have a genetic component. To better understand disease, researchers led by the Garvan Institute of Medical Research are analysing genetic information to determine what keeps us healthy.

Genetics

How to analyze your genome; Part I—Mitochondrial DNA

Genome analysis today is basically blind. It typically proceeds by randomly inspecting a smattering of possible variants that are only loosely associated with some disease or physical trait. Unless you already have a major ...

Genetics

Mitochondrial disease patients face difficult road to diagnosis

A new study documents the prolonged and difficult path patients face before they are diagnosed with mitochondrial diseases, a group of rare, debilitating genetic disorders. The study was led by researchers at Columbia University ...

Genetics

What are mitochondria and how did we come to have them?

We've probably all heard of mitochondria, and we may even remember learning in school that they are the "powerhouses of the cell" – but what does that actually mean, and how did they evolve? To answer this question, we ...

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