Fanconi anemia (FA) is a genetic disease affecting small children characterized by bone-marrow failure, developmental abnormalities and predisposition to multiple forms of cancer. The molecular mechanisms behind FA are inherited ...
Oct 14, 2020
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Researchers trying to turn off a gene that allows cancers to spread have made a surprising U-turn. By making the gene overactive and functional in the hearts of mice, they have triggered heart cell regeneration. Since adult ...
Apr 14, 2020
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A multi-institutional group of researchers led by Children's Hospital of Philadelphia (CHOP) has linked a strong cancer driver gene to changes in proteins that regulate alternative splicing. The researchers created new computational ...
Feb 17, 2020
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MYC is a family of three related proteins that are overexpressed in cancer and which contribute to an estimated 100,000 cancer deaths annually in the United States.
Jan 31, 2020
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Cancer-promoting genes MYC and TWIST1 co-opt immune system cells to enable cancer cells to spread, but blocking a key step in this process can help prevent the disease from developing.
Jan 14, 2020
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Researchers have long known that some genes can cause cancer when overactive, but exactly what happens inside the cell nucleus when the cancer grows has so far remained enigmatic. Now, researchers at Karolinska Institutet ...
Dec 2, 2019
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What molecular event happens for prostate cancer to progress faster and to be deadlier when patients eat a high-fat diet? This is the question Dr. David P. Labbé, a scientist at the Research Institute of the McGill University ...
Nov 29, 2019
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Versions of an antibiotic drug called DON first isolated from soil bacteria more than 60 years ago have shown promising signs of extending survival in mice models of especially lethal pediatric brain tumors marked by the ...
Sep 23, 2019
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A Ludwig Cancer Research study has uncovered a novel vulnerability in tumors that are driven by a common cancer gene known as MYC. Such cancers, it found, are highly dependent on the cell's machinery for making fats and other ...
Aug 22, 2019
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Malignant rhabdoid tumor (MRT) is one of the most aggressive and lethal childhood cancers.
May 2, 2019
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