HIV & AIDS
Simulations show how HIV sneaks into the nucleus of the cell
Because viruses have to hijack someone else's cell to replicate, they've gotten very good at it—inventing all sorts of tricks.
Jan 25, 2024
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News tagged with nuclear pores
Oncology & Cancer
Nuclear gatekeeper could block undruggable prostate cancer targets
Certain molecular drivers of cancer growth are "undruggable—it's been nearly impossible to develop chemicals that would block their action and prevent cancer growth. Many of these molecules function by passing cancer-promoting ...
Aug 9, 2018
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Oncology & Cancer
Brain cancer linked to nuclear pore alterations
Several types of cancer are believed to be linked to alterations of macromolecular structures known as nuclear pore complexes (NPCs). These structures are embedded in the nuclear envelope, a membrane barrier that separates ...
Sep 15, 2023
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Neuroscience
In Huntington's disease, traffic jams in the cell's control center kill brain cells
Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center—the nucleus—appear to be a ...
May 4, 2017
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Oncology & Cancer
New opportunities for targeting overactive cancer genes
Anita Göndör's group has identified a new mechanism underlying the pathological over-expression of cancer genes. The results, which are published in Nature Communications show that signals in the environment of the cancer ...
Jan 12, 2022
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Medical research
How does HIV get into the cell's center to kickstart infection?
UNSW medical researcher Dr. David Jacques and his team have discovered how the human immunodeficiency virus (HIV) breaches the cell nucleus to establish infection, a finding that has implications beyond HIV biology.
Jan 24, 2024
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Medical research
Study explains why adults' hearts don't regenerate
As heart cells mature in mice, the number of communication pathways called nuclear pores dramatically decreases, according to new research from University of Pittsburgh and UPMC scientists. While this might protect the organ ...
Oct 24, 2022
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Immunology
Nuclear pore functions are essential for T cell survival
Nuclear pore complexes in the nuclear membrane not only control the transport of molecules into and out of the nucleus—they play an essential role in the survival of T cells. A new study by Sanford Burnham Prebys Medical ...
May 7, 2018
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Neuroscience
Researchers identify a cellular defect common to familial and sporadic forms of ALS
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal degenerative disease affecting the nerve cells in the brain and spinal cord responsible for controlling voluntary muscle movement. "Sporadic" or non-inherited ...
Jul 28, 2021
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Genetics
Multifunctional protein contributes to blood cell development
Like an actor who excels at both comedy and drama, proteins also can play multiple roles. Uncovering these varied talents can teach researchers more about the inner workings of cells. It also can yield new discoveries about ...
Dec 21, 2017
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