One of the main challenges in oncology is the development of drugs against KRAS oncogenes. These oncogenes—genes that cause cancer when mutated—are responsible for a quarter of all human cancers, including the three tumor ...
Sep 1, 2022
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Pancreatic cancer has a significantly poor prognosis; therefore, the development of effective treatments is an unmet clinical need. The major drawback in this field was the lack of useful model animals, which delayed the ...
Apr 22, 2022
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An enzyme that has been identified as instrumental in the progression of many types of cancer is meeting its match in inhibitors synthesized and evaluated by University of Colorado (CU) Cancer Center researchers.
Apr 7, 2022
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Using the developing eye of the fruit fly as a test platform, researchers found that RPS-12 protein overproduction appears to trigger triple-negative breast cancer and possibly some other malignancies. The protein indirectly ...
Jan 29, 2021
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Cancer research is a field that has been especially dependent on public funding. The National Cancer Institute (NCI), an independent institute of the National Institutes of Health (NIH), was established in 1937 to provide ...
Jul 8, 2019
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A University of Hawai'i Cancer Center researcher has identified how some cancer cells are made to move during metastasis. The research provides a better understanding of how cancer spreads and may create new opportunities ...
Dec 27, 2017
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Cancers driven by the RAS oncogene are aggressive and difficult to treat, and thus far precision drugs haven't been able to target the mutant RAS gene successfully.
Apr 3, 2017
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In a study published in the scientific journal Oncotarget, researchers from Uppsala University show how the protein EZH2 affects the development of multiple myeloma, and that inhibition of EZH2 could be used as a new strategy ...
Jan 12, 2017
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For the first time, researchers have shown that an enzyme key to regulating gene expression—and also an oncogene when mutated—is critical for the expression of numerous inflammatory compounds that have been implicated ...
Feb 3, 2016
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Proteins are like bricks that form our cells and they are built by the orders given by our genetic material, DNA. In human diseases, eventually DNA alterations modify proteins and they don't do their normal function, either ...
Dec 16, 2015
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