Medical research
At last, a reason why stress causes DNA damage
For years, researchers have published papers that associate chronic stress with chromosomal damage.
Aug 21, 2011
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News tagged with p53 pathway
Oncology & Cancer
Cancer suppressor gene links metabolism with cellular aging
The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Jan 13, 2013
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Oncology & Cancer
Researchers identify new target for treatment of aggressive childhood brain tumors
More children die of brain tumors than any other type of cancer. Diffuse midline gliomas (DMGs) are a particularly deadly kind, and are difficult to treat with drugs or surgery because they're in an important part of the ...
Feb 4, 2022
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Oncology & Cancer
How a metabolic pathway promotes breast cancer metastasis
A metabolic pathway that is up-regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biology. The ...
Apr 6, 2016
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Oncology & Cancer
Unexpected link between most common cancer drivers may yield more effective drugs
Two of the most common genetic changes that cause cells to become cancerous, which were previously thought to be separate and regulated by different cellular signals, are working in concert, according to new research from ...
Jul 7, 2022
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Oncology & Cancer
Toxic peptide payload can be delivered exclusively to cancer cells
A drug that can kill cancer cells while leaving normal cells unharmed may be within our grasp thanks to research from A*STAR, although the approach is still several years away from clinical trials.
Jul 27, 2016
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Oncology & Cancer
Cancer cell metabolism kills
Adenosine-5'-triphosphate (ATP) is the main energy source for all forms of work inside our cells. Scientists from the University of Helsinki, Finland, have found that even a short-term shortage of ATP supply can be fatal ...
Apr 15, 2013
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Oncology & Cancer
Deficiency in p53 anti-tumor protein delays DNA repair after radiation
Researchers at Moffitt Cancer Center have found that a deficiency in an important anti-tumor protein, p53, can slow or delay DNA repair after radiation treatment. They suggest that this is because p53 regulates the expression ...
Apr 23, 2013
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Obstetrics & gynaecology
Common diabetes drug may help prevent preterm birth
Metformin, a medication routinely used by millions of people with type 2 diabetes, may also play an unexpected role in blocking a significant cause of preterm birth, according to research findings published July 25.
Jul 25, 2016
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Oncology & Cancer
Molecular relative of p53 tumor suppressor protein also helps cancer cells thrive
They say you can pick your friends, but not your family. The same may hold true for related proteins. The protein TAp73 is a relative of the well-known, tumor-suppressor protein p53. It shares extensive common gene sequences ...
Jul 16, 2013
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