A commercially available drug may help drastically reduce two side effects of opioid painkillers—a growing tolerance and a paradoxical increased sensitivity to pain—without affecting the drugs' ability to reduce pain, ...
Jan 17, 2017
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The spinal surgery David B. underwent in November wasn't his first – but it was the first time he was awake for a procedure.
Mar 6, 2019
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In a study conducted by researchers at Hospital for Special Surgery (HSS), cumulative opioid use was reduced by 30% in a patient group that received duloxetine after total knee arthroplasty (TKA) compared with patients who ...
May 13, 2021
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A new study published in the Journal of Clinical Investigation has identified a key molecule that contributes to painful diabetic neuropathy, an incurable nerve disease that affects about one-quarter of all patients with ...
May 1, 2018
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The painful condition known as "tennis elbow" results from overuse of the tendons in the forearm, typically in a patient's dominant arm. A repetitive stress injury, tennis elbow affects not just athletes, but also tradesmen, ...
Nov 1, 2018
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For patients with severe arthritis of the ankle, total ankle arthroplasty (TAA) provides better long-term function than ankle arthrodesis (AA), reports a study in The Journal of Bone & Joint Surgery.
May 19, 2021
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Pharmaceutical giants GlaxoSmithKline and Pfizer on Wednesday announced a merger of their consumer healthcare units that produce over-the-counter medicines.
Dec 19, 2018
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Activity in a brain area known as the dorsal posterior insula is directly related to the intensity of pain, a brain imaging study of 17 people has found.
Mar 9, 2015
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Researchers have identified a brain mechanism that could be a drug target to help prevent tolerance and addiction to opioid pain medication, such as morphine, according to a study by Georgia State University and Emory University.
Aug 22, 2016
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Opioid receptors are proteins in the central nervous system that are targeted by opioid drugs for pain relief. There are three subtypes of opioid receptors, MOP, DOP and KOP, in addition to the opioid-related NOP receptor.
