'Ouch zone' in the brain identified

March 9, 2015
Credit: Rice University

Activity in a brain area known as the dorsal posterior insula is directly related to the intensity of pain, a brain imaging study of 17 people has found.

Researchers at the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain used a new brain imaging technique to look at people experiencing over many hours. Activity in only one brain area, the dorsal posterior insula, reflected the participants' ratings of how much the pain hurt.

These results, published in the journal Nature Neuroscience, could help detect pain in people with limited communication abilities, such as those in a coma, small children and dementia patients.

"We have identified the brain area likely to be responsible for the core, 'it hurts', experience of pain," said Professor Irene Tracey, University of Oxford, whose team made the discovery. "Pain is a complex, multidimensional experience, which causes activity in many brain regions involved with things like attention, feeling emotions such as fear, locating where the pain is, and so on. But the dorsal posterior insula seems to be specific to the actual 'hurt level' of pain itself."

"We were able to find this area by developing a new method of tracking , based on a technique called arterial spin labelling. This allowed us to look at more complex brain states that stretch over much longer periods. By tracking pain felt over many hours, we were able to filter out more momentary experiences, such as variations in attention or fear," said Professor Tracey.

The research team tracked brain activity in 17 healthy volunteers who had a cream containing capsaicin (the active ingredient in chillies) applied onto their right leg, causing a . The volunteers indicated how much this burning sensation hurt.

Once the began to fade, the researchers 'rekindled' the sensation by putting a hot water bottle where the cream was applied. A few minutes later, they provided by switching to a cooling water bottle. The volunteers' ratings of how much the pain hurt accordingly went up and then down.

Activity changes in the dorsal posterior insula tracked these changes in the volunteers' ratings of pain.

The research team plans to verify these results by attempting to switch off this brain region in relevant patients suffering from intractable pain. The team hopes that changing activity in the dorsal posterior insula will help to treat pain where other methods have failed.

Explore further: Brain imaging reveals dynamic changes caused by pain medicines

More information: 'The dorsal posterior insula subserves a fundamental role in human pain', is published in Nature Neuroscience, DOI: 10.1038/nn.3969

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dan42day
not rated yet Mar 09, 2015
If this pans out, it will be revolutionary! No more addictive pain medication or questionable surgical procedures to relieve various aches and pains. Let's just hope that DARPA doesn't figure out a way to use it to keep injured soldiers fighting, or as a shortcut to keep them from insisting on needed treatments at the VA.

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