Scientists have developed 3D mini-organs from human fetal brain tissue that self-organize in vitro. These lab-grown organoids open up a brand-new way of studying how the brain develops. They also offer a valuable means to ...
Jan 8, 2024
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Immunotherapy using modified chimeric antigen receptor (CAR) T cells has greatly improved survival rates for pediatric patients with relapsed and recurrent leukemia. However, these therapies are not as effective in treating ...
Nov 30, 2023
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Essential features of the cortex, an important part of the human brain and its development, are more accurately captured in organoids generated by researchers of the Princess Máxima Center for pediatric oncology and the ...
Nov 28, 2023
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Researchers from Children's Hospital of Philadelphia (CHOP), the Alex's Lemonade Stand Foundation Childhood Cancer Data Lab, the Children's Brain Tumor Network (CBTN), the Pacific Pediatric Neuro-Oncology Consortium (PNOC), ...
May 31, 2023
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Two recent papers from researchers in the Children's Hospital of Philadelphia (CHOP) Cancer Center have advanced the understanding of treatment-resistant pediatric tumors, both in assessing a novel treatment and in characterizing ...
Apr 27, 2023
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Pediatric solid tumors make up approximately 40% of all childhood cancers. While pediatric cancer is rare, children can develop a wide range of tumor types, located in different parts of the body, which can make the differential ...
Mar 3, 2023
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Investigators have identified previously unknown sets of epigenetic changes in pediatric brain tumors, which could serve as novel therapeutic targets and provide alternative treatment options for patients, according to a ...
Dec 6, 2022
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While substantial strides have been made against some types of childhood cancers, high-grade gliomas still lack effective treatments.
Oct 13, 2021
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A comprehensive "proteogenomic" analysis of the proteins, genes, and RNA transcription involved in pediatric brain tumors has yielded a more complete understanding of these tumors, which are the leading cause of cancer-related ...
Nov 25, 2020
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Research performed over the last several decades has led to an increased understanding of the genetics of cancer. The clinical application of this knowledge for pediatric cancer has lagged behind studies performed for adults. ...
Mar 15, 2019
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