It is now widely understood that cancer is a disease of acquired defects in genes and gene function. An article published Feb. 9 in Science, and authored by Andrew Feinberg, M.D., of the Johns Hopkins Kimmel Cancer Center ...
Feb 10, 2023
0
51
Led by researchers from the University of California at Irvine, a new study reveals that a long-lived Chilean rodent, called Octodon degus (degu), is a useful and practical model of natural sporadic Alzheimer's disease. The ...
Dec 19, 2022
0
33
A team of researchers at Indiana University School of Medicine has developed specialized bioinformatics software designed to identify rare genetic variants in whole-genome sequencing studies. Zilin Li, Ph.D., assistant professor ...
Nov 8, 2022
0
118
Regeneration in the CNS is a rare event and strongly limited to the replacement of so-called oligodendroglial cells and their electrically insulating elements of the axons, called myelin sheaths. This is also true for multiple ...
Aug 25, 2022
0
44
Copper is essential for many cellular functions, including cellular respiration, antioxidant defense, neurotransmitter biosynthesis and neuropeptide amidation, among others. Until recently, only two inborn errors of copper ...
Aug 18, 2022
0
60
A team of researchers from the Department of Veterans Affairs, Oak Ridge National Laboratory, Harvard's T.H. Chan School of Public Health, Harvard Medical School and Brigham and Women's Hospital has developed a novel, machine ...
Apr 28, 2022
0
49
Neuroscientists from St. Petersburg University, led by Professor Allan V. Kalueff, in collaboration with an international team of IT specialists, have become the first in the world to apply the artificial intelligence (AI) ...
Apr 14, 2022
0
36
Three newly-defined phenotypes (observable characteristics or traits for an individual) that capture genetic associations which may provide protection against SARS-CoV-2, are presented in a study published in Nature Genetics. ...
Apr 12, 2022
0
75
Mutant mice are providing scientists with a new neurobiological framework to understand the brain changes observed in distractible humans who carry a common gene variant whose frequency has been associated with Attention ...
Apr 7, 2022
0
321
Cancer stem cells (CSCs), a key driver behind malignant cancer progression, are self-renewing, highly metastatic and therapeutically resistant. As cancer progresses, cancer cells display a phenotypic plasticity between the ...
Apr 1, 2022
0
10
A phenotype is an organism's observable characteristics or traits: such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior (such as a bird's nest). Phenotypes result from the expression of an organism's genes as well as the influence of environmental factors and the interactions between the two.
The genotype of an organism is the inherited instructions it carries within its genetic code. Not all organisms with the same genotype look or act the same way because appearance and behavior are modified by environmental and developmental conditions. Similarly, not all organisms that look alike necessarily have the same genotype.
This genotype-phenotype distinction was proposed by Wilhelm Johannsen in 1911 to make clear the difference between an organism's heredity and what that heredity produces. The distinction is similar to that proposed by August Weismann, who distinguished between germ plasm (heredity) and somatic cells (the body). The Genotype-Phenotype concept should not be confused with Francis Crick's central dogma of molecular biology which is a statement about the directionality of molecular sequential information flowing from DNA to protein (but which cannot become transferred from proteins).
This text uses material from Wikipedia, licensed under CC BY-SA
