Using machine learning to save lives in the ER
Worldwide, approximately 4.5 million people die of traumatic injury every year. Many of these patients die from blood loss.
Mar 26, 2024
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Worldwide, approximately 4.5 million people die of traumatic injury every year. Many of these patients die from blood loss.
Mar 26, 2024
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Cancer cells are notorious for rapidly changing their phenotype, driving within-host spread and evading treatment. Scientists in Plön have used a mathematical model to understand the role of a signal used by cancer cells ...
Oct 26, 2023
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The Neolithic Tyrolean Iceman "Ötzi" has been studied thoroughly in the past. But the latest installment, in which researchers have generated a high-coverage genome to learn more about his genetic history, still offers some ...
Aug 16, 2023
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In a pilot study of 165 people, Mayo Clinic researchers looked at the effectiveness of two different approaches to weight loss: a standard lifestyle intervention and individualized therapy. The standard lifestyle intervention ...
Jul 21, 2023
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Researchers from GeneDx have published a paper titled "Multiscale analysis of pangenomes enables improved representation of genomic diversity for repetitive and clinically relevant genes" in Nature Methods. The work details ...
Jun 26, 2023
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It is now widely understood that cancer is a disease of acquired defects in genes and gene function. An article published Feb. 9 in Science, and authored by Andrew Feinberg, M.D., of the Johns Hopkins Kimmel Cancer Center ...
Feb 10, 2023
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Led by researchers from the University of California at Irvine, a new study reveals that a long-lived Chilean rodent, called Octodon degus (degu), is a useful and practical model of natural sporadic Alzheimer's disease. The ...
Dec 19, 2022
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A team of researchers at Indiana University School of Medicine has developed specialized bioinformatics software designed to identify rare genetic variants in whole-genome sequencing studies. Zilin Li, Ph.D., assistant professor ...
Nov 8, 2022
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Regeneration in the CNS is a rare event and strongly limited to the replacement of so-called oligodendroglial cells and their electrically insulating elements of the axons, called myelin sheaths. This is also true for multiple ...
Aug 25, 2022
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Copper is essential for many cellular functions, including cellular respiration, antioxidant defense, neurotransmitter biosynthesis and neuropeptide amidation, among others. Until recently, only two inborn errors of copper ...
Aug 18, 2022
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A phenotype is an organism's observable characteristics or traits: such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior (such as a bird's nest). Phenotypes result from the expression of an organism's genes as well as the influence of environmental factors and the interactions between the two.
The genotype of an organism is the inherited instructions it carries within its genetic code. Not all organisms with the same genotype look or act the same way because appearance and behavior are modified by environmental and developmental conditions. Similarly, not all organisms that look alike necessarily have the same genotype.
This genotype-phenotype distinction was proposed by Wilhelm Johannsen in 1911 to make clear the difference between an organism's heredity and what that heredity produces. The distinction is similar to that proposed by August Weismann, who distinguished between germ plasm (heredity) and somatic cells (the body). The Genotype-Phenotype concept should not be confused with Francis Crick's central dogma of molecular biology which is a statement about the directionality of molecular sequential information flowing from DNA to protein (but which cannot become transferred from proteins).
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