Canadian immunologists have identified a mechanism that promotes the activation of T cell receptors by altering how one of its components interacts with the cell membrane.
(Medical Xpress)—Neuroscience typically proceeds by trimming back previous overly dogmatic statements. Such is the case with new findings that proteins are locally manufactured to order throughout an extended neuronal tree. ...
(Medical Xpress)—To move material in bulk, the standard shipping container used by cells, is the vesicle. These approximately 40-micron sized spheres are essentially recyclable grocery bags that can be loaded and adorned ...
Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have built and demonstrated the potential efficacy of a new chimeric antigen receptor (CAR) T-cell-based immunotherapy specifically designed to treat patients ...
Feb 16, 2024
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Sensory neurons play a crucial role in the perception of "hot" and "cold". They express a group of ion channels called thermosensitive TRP channels. For example, TRPV1 (activated above 43°C) and TRPM8 (activated below 29°C) ...
Jul 21, 2023
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In the brain, neurons communicate via neurotransmitters, which trigger electrical signals in downstream neurons by binding and activating specific receptors. Neurotransmitters are released through the fusion of synaptic vesicles, ...
Jun 6, 2023
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Researchers at UC Davis are the first to report how a specific type of brain cells, known as oligodendrocyte-lineage cells, transfer cell material to neurons in the mouse brain. Their work provides evidence of a coordinated ...
Apr 17, 2023
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Northwestern Medicine investigators have discovered that dopaminergic neurons in the substantia nigra utilize a specific ion channel to meet anticipated energy needs, according to findings published in Science Advances.
Oct 20, 2022
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Peripheral membrane proteins temporarily bind to cell membranes, a necessary step for them to be able to fulfill their biological function. To do this, certain enzymes that catalyze their lipid modification come into action. ...
Apr 25, 2022
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A study published in Nature Communications today presents a compelling new evidence about what a key protein called alpha-synuclein actually does in neurons in the brain.
Feb 10, 2021
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The cell membrane (also called the plasma membrane or plasmalemma) is the biological membrane separating the interior of a cell from the outside environment.
It is a semipermeable lipid bilayer found in all cells. It contains a wide variety of biological molecules, primarily proteins and lipids, which are involved in a vast array of cellular processes such as cell adhesion, ion channel conductance and cell signaling. The plasma membrane also serves as the attachment point for both the intracellular cytoskeleton and, if present, the extracellular cell wall.
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