The first example of prion strains that replicate independently in vitro and in vivo suggests that strain diversity may be greater than previously thought, according to a study published October 18 in the open-access journal ...
Oct 18, 2018
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New research led by Marco Prado, PhD, of Western University has identified a pathway used by the brain to try to protect itself from toxicity that occurs with Alzheimer's disease (AD). Prado and his colleagues at the Robarts ...
Oct 15, 2013
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Neurodegenerative diseases are characterized by the deposition of clumped proteins in the brain and progressive neuronal cell death. Although the causal link between protein aggregates and neurodegeneration is clear, how ...
Dec 4, 2023
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A new study of prion diseases, using a human cerebral organoid model, suggests there is a substantial species barrier preventing transmission of chronic wasting disease (CWD) from cervids—deer, elk and moose—to people. ...
May 17, 2024
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A blood test accurately screened for infection with the agent responsible for variant Creutzfeldt-Jakob disease (vCJD), a fatal neurological disease.
Mar 4, 2014
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The cellular prion protein (PrPC) has the ability to protect the brain's neurons. Although scientists have known about this protective physiological function for some time, they were lacking detailed knowledge of the molecular ...
Dec 17, 2014
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A new model of fatal brain diseases is being developed in the fruit fly by a team led by Dr Raymond Bujdoso at the University of Cambridge, and could lead to a low cost, fast and efficient blood test to diagnose - and prevent ...
Oct 13, 2016
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Every year in Catalonia 15 new cases of Creutzfeldt Jakob Disease are diagnosed. It is a deadly prion disease whose cause is unknown and has no treatment, though it is very similar to mad cow disease, also brought on by prions ...
May 29, 2019
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Aging-related cognitive decline is an early symptom of Alzheimer's disease and other dementias, and on its own can have substantial consequences on an individual's ability to perform important everyday functions. Despite ...
Sep 16, 2022
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A hamster prion that replicated under conditions of low RNA levels in mouse brain material resulted in altered disease features when readapted and transmitted back to hamsters, according to new research presented in PLOS ...
Jun 21, 2018
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