A new mechanism to inhibit proteasomes, protein complexes that are a target for cancer therapy, is the topic of an article published in the journal Chemistry & Biology. The first author of the study is Daniela Trivella, researcher ...
Sep 9, 2014
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A soccer team is made up of 11 players with each person having a specific role and place on the field. In the world of biology, each individual cell also has many moving parts and pieces, each with specific roles and places ...
Jul 11, 2019
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UNSW medical researcher Dr. David Jacques and his team have discovered how the human immunodeficiency virus (HIV) breaches the cell nucleus to establish infection, a finding that has implications beyond HIV biology.
Jan 24, 2024
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Hokkaido University scientists have identified new targets for treating an aggressive form of adult leukemia with existing drugs. The findings were published in the journal Blood.
Mar 31, 2022
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Within the brain and other parts of the nervous system, synapses are key junctional points in between neurons (the nerve cells) where critical signals are transmitted. More specifically, the "glutamatergic" synapses are the ...
Oct 6, 2021
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The gene p53 has been described as the "guardian of the genome" due to its prominent role in preventing genetic mutations. More than half of all cancers are thought to originate from p53 mutations or loss of function, and ...
Dec 14, 2015
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There is strong evidence that the protein complex APC/C may function as a tumor suppressor in multiple cancers including lymphoma, colorectal and breast cancer, and now melanoma. A new study has revealed that a genetic mutation ...
Sep 2, 2015
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Primates are among the most intelligent creatures with distinct cognitive abilities. Their brains are relatively large in relation to their body stature and have a complex structure. However, how the brain has developed over ...
May 16, 2023
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Like wrenches made of Legos, SWI/SNF chromatin remodeling complexes tighten or loosen DNA in our cells to control how genes are turned on and made into proteins. When assembled correctly, these complexes play a crucial role ...
Sep 8, 2020
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An international team of scientists, led by the University of Bristol, has been investigating how the SARS-CoV-2 virus, the coronavirus responsible for the COVID-19 pandemic, manipulates host proteins to penetrate into human ...
Jun 14, 2022
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