Medical research
New gears in your sleep clock
The circadian cycle, a long-studied factor controlling human sleep cycles, actually has two forms, one that keeps a key protein stable, and another that promotes its degradation.
Jul 12, 2018
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News tagged with protein kinase
Oncology & Cancer
Genes of different importance for brain cancer
Two genes play important roles for the formation of malignant cancer in the brain. One gene prevents the formation of the tumour, while another gene promotes the tumour. This is shown in a new dissertation at Umeå University, ...
May 24, 2018
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Oncology & Cancer
Researchers uncover up to 100 potential drug targets for cancer
Protein researchers from the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen have used mass spectrometry-based proteomics to uncover a number of proteins that could play a critical role ...
May 15, 2018
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Oncology & Cancer
Tumor suppressor protein targets liver cancer
Salk Institute scientists, together with researchers from Switzerland's University of Basel and University Hospital Basel, discovered a protein called LHPP that acts as a molecular switch to turn off the uncontrolled growth ...
Mar 29, 2018
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Oncology & Cancer
Old drug may have new tricks for fighting cancer
In recent years, a powerful suite of drugs known as kinase inhibitors have been developed to treat cancer and other diseases. Primary targets of such drugs include a family of receptor tyrosine kinases (RTKs) which protrude ...
Feb 5, 2018
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Immunology
New therapeutic approach for advanced lung disease
Researchers have demonstrated the potential of a new class of drugs for the treatment of refractory chronic obstructive pulmonary disease (COPD). Incurable to date, the disease is one of the most frequent causes of death ...
Jan 15, 2018
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Oncology & Cancer
New kinase detection method helps identify targets for developing cancer drugs
Purdue University researchers have developed a high-throughput method for matching kinases to the proteins they phosphorylate, speeding the ability to identify multiple potential cancer drug targets.
Sep 21, 2017
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Medical research
Obese inducing brain mechanism
Leptin is an adipocyte-derived hormone that stimulates hypothalamic neurons to strongly inhibit food intake. Leptin signaling in the hypothalamus, a part of the mid-brain, thus plays a crucial role in the regulation of body ...
Sep 15, 2017
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Neuroscience
Agent clears toxic proteins and improves cognition in neurodegeneration models
Researchers have found cell receptors abnormally overexpressed in post-mortem brains of those with Parkinson's and Alzheimer's diseases, and that they can be inhibited in animal models to clear toxic protein buildup, reduce ...
Jul 16, 2017
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124
Medical research
Localized signaling islands in cells: New targets for precision drug design
New research overturns long-held views on a basic messaging system within living cells. Key cellular communication machinery is more regionally constrained within the cell than previously thought. The findings suggest new ...
Jun 22, 2017
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