Cardiology

Not enough women included in some heart disease clinical trials

Women are underrepresented in clinical trials for heart failure, coronary artery disease and acute coronary syndrome but proportionately or overrepresented in trials for hypertension, atrial fibrillation and pulmonary arterial ...

Medical research

Crosstalk between cells plays role in pulmonary hypertension

Pulmonary hypertension is a type of high blood pressure that affects blood vessels in the lungs. Once diagnosed, patients have limited treatment options, and many do not live beyond seven years. In a new study, scientists ...

Diseases, Conditions, Syndromes

Erectile dysfunction drugs may help treat many other conditions

A new British Journal of Pharmacology review examines how phosphodiesterase-5 (PDE5) inhibitors, which were originally approved to treat erectile dysfunction, are finding clinical uses for a wide variety of conditions.

Cardiology

Hemodynamic parameters predict outcome in PH-HFpEF

(HealthDay)—The hemodynamic parameters transpulmonary gradient, pulmonary vascular resistance, and diastolic pulmonary gradient are associated with mortality and cardiac hospitalization in pulmonary hypertension (PH) in ...

Medical research

Mitochondrial mutations and disease

Mitochondria are cellular organelles with their own DNA. Their role in power generation makes them susceptible to oxidative damage, including the formation of DNA-damaging chemical complexes called adducts.

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