Bromodomain-containing protein 7 (BRD7) was initially identified as a tumor suppressor, but further research has shown it has a broader role in other cellular processes, including the remodeling of chromosomes and cell cycle ...
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The rapidly escalating prevalence of overweight and obesity poses a significant medical challenge worldwide. In addition to people's changing lifestyles, genetic factors also play a key role in the development of obesity.
Apr 30, 2024
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For patients with relapsed or refractory CD7-positive leukemia or lymphoma, sequential CD7 chimeric antigen receptor (CAR) T-cell therapy followed by haploidentical hematopoietic stem-cell transplantation (HSCT) is safe and ...
Apr 25, 2024
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Researchers at Texas Children's Cancer Center and the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children's Hospital and Houston Methodist have published results of a Phase I clinical trial of a ...
Apr 24, 2024
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A drug that can help prevent migraines could soon be available on the NHS. Atogepant (brand name: Aquipta) was recently recommended by the National Institute for Health and Care Excellence (NICE) to prevent episodic and chronic ...
Apr 23, 2024
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Autoimmune disease (AID) refers to the condition in which the immune system identifies the body's own cells and tissues as foreign, resulting in systemic inflammation. The immune system's self-attack via autoreactive B and ...
Apr 22, 2024
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Through millions of years of evolutionary refinement, the human body has developed a sophisticated surveillance mechanism—the immune system. This intricate network is constantly scanning the body for invaders such as bacteria, ...
Apr 17, 2024
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In a new study, a Johns Hopkins Medicine-led research team reports that social stress during adolescence in female mice later results in prolonged elevation of the hormone cortisol after they give birth. The researchers say ...
Apr 16, 2024
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Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Drugs that target opioid receptors sometimes have severe side effects. An international team of researchers has taken a ...
Apr 12, 2024
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In a world-first, QIMR Berghofer scientists have discovered the mechanism that causes severe inflammation among millions of people with chronic liver disease.
Apr 12, 2024
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In biochemistry, a receptor is a protein molecule, embedded in either the plasma membrane or cytoplasm of a cell, to which a mobile signaling (or "signal") molecule may attach. A molecule which binds to a receptor is called a "ligand," and may be a peptide (such as a neurotransmitter), a hormone, a pharmaceutical drug, or a toxin, and when such binding occurs, the receptor undergoes a conformational change which ordinarily initiates a cellular response. However, some ligands merely block receptors without inducing any response (e.g. antagonists). Ligand-induced changes in receptors result in physiological changes which constitute the biological activity of the ligands.
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