Researchers have found that levels of a regulatory protein called ATF4, and the corresponding levels of the molecules whose expression it controls, are elevated in the livers of mice exposed to multiple interventions known ...
Sep 15, 2014
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Many proteins undergo an assembly line-style process of glycosylation as they travel from a cellular structure called the endoplasmic reticulum (ER) to the Golgi apparatus and on through its various compartments, after which ...
Aug 27, 2014
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The protein mTOR is a central controller of growth and metabolism. Deregulation of mTOR signaling increases the risk of developing metabolic diseases such as diabetes, obesity and cancer. In the current issue of the journal ...
Aug 11, 2014
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St. Jude Children's Research Hospital scientists have mapped the structural details of how p53 attaches to its regulatory protein, called BCL-xL, in the cell. The protein p53 is a key activator of the cell's protective machinery ...
May 15, 2014
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People with mutations in a gene called BSCL2 suffer from a rare medical condition known as lipodystrophy in which fat tissue is lost from where it is supposed to accumulate while being deposited at unusual sites around the ...
Feb 12, 2014
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The increased activation of a key oncogene in head and neck cancers could be the result of mutation and dysfunction of regulatory proteins that are supposed to keep the gene, which has the potential to cause cancer, in check, ...
Jan 6, 2014
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Scientists at Rutgers University studying the cause of a rare childhood disease that leaves children unable to walk by adolescence say new findings may provide clues to understanding more common neurodegenerative diseases ...
Oct 27, 2013
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Imagine mucus—which most people find unpleasant—actually helping your body maintain its equilibrium, prevent inflammation, and reduce food allergy problems.
Sep 26, 2013
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(Medical Xpress)—A small molecule developed at Yale University to limit damage done by ischemia – restricted blood flow – during heart attacks or surgery has been shown to reduce by 40 percent the amount of heart muscle ...
Sep 5, 2013
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The hepatitis C virus hijacks the body's immune system, leaving T cells unable to function. A new study in animal models suggests that blocking a protein that helps the virus thrive could restore immune function, allowing ...
Sep 3, 2013
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