Oncology & Cancer

Understanding the DNA repair toolkit to chart cancer evolution

The ongoing fight of science against cancer has made great strides, but cancer cells have not made it easy. The complexity of cancer cells and their adaptive evolutionary nature complicate the search for effective cures. ...

Oncology & Cancer

Drug makes tumors more susceptible to chemo

Many chemotherapy drugs kill cancer cells by severely damaging their DNA. However, some tumors can withstand this damage by relying on a DNA repair pathway that not only allows them to survive, but also introduces mutations ...

Medications

Potential drug targets for ALS and FTD identified in two studies

A pair of collaborative studies led by Fen-Biao Gao, Ph.D., have identified two potential drug targets for the diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The studies, which appear in Nature ...

Medical research

How cells detect, mend DNA damage may improve chemotherapy

The busy world inside a cell is directed by its DNA blueprint. When the blueprints are altered, cells can sicken, die or become cancerous. To keep DNA in working order, cells have ways to detect and mend damaged DNA.

Diseases, Conditions, Syndromes

Signaling pathways in the pathogenesis of diamond blackfan anemia

Diamond Blackfan Anemia (DBA) is a condition that is characterized by a failure of the bone marrow to produce red blood cells, congenital abnormalities, and a predisposition to cancer. Current treatment options, including ...

Oncology & Cancer

Cancer cells hijack DNA repair networks to stay alive, study shows

Research by scientists at the University of Pittsburgh Cancer Institute (UPCI) has revealed how cancer cells hijack DNA repair pathways to prevent telomeres, the endcaps of chromosomes, from shortening, thus allowing the ...

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