Inhibiting telomerase, an enzyme that rescues malignant cells from destruction by extending the protective caps on the ends of chromosomes, kills tumor cells but also triggers resistance pathways that allow cancer to survive ...
Feb 21, 2012
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Using a pair of powerful genome-search techniques, researchers from the Harvard School of Public Health (HSPH), Harvard University, and the Broad Institute have identified several genes that may be implicated in the malaria ...
Apr 21, 2011
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Researchers led by the University of Tsukuba conducted a gene expression analysis at the single-cell level on pancreatic islets from prediabetic and diabetic mouse models. Their results are published in the journal Diabetes.
Nov 21, 2023
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Small cell lung cancer accounts for about 15% of all diagnosed lung cancers and is still associated with a high mortality rate. SCLC tumors often develop resistance to chemotherapy and thus poor prognosis is due to tumor ...
Sep 21, 2023
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Type 2 diabetes (T2D) is characterized by persistent hyperglycemia (high glucose in blood) that leads to hypoxia (low oxygen condition) in pancreatic β-cells.
Sep 20, 2023
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Type 2 diabetes is a chronic disease in which the body does not produce enough insulin, or does not use it efficiently. It is caused by the combination of a genetic predisposition to obesity, sedentarism and an unhealthy ...
Mar 23, 2023
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For the 280 million people suffering from depression globally, relief cannot come fast enough. Monoaminergic antidepressants, including selective serotonin reuptake inhibitors (SSRIs) take weeks to months to take effect and ...
May 25, 2022
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For patients with acute lymphoblastic leukemia with resistance to C19 CAR T-cell therapy, resistance mechanisms that can be detected prior to treatment have been identified, according to a study presented at the annual meeting ...
Apr 12, 2022
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Could fluctuations in body weight resulting from drastically cutting and increasing calories lead to physiological changes that raise the risk of heart disease or diabetes later in life?
Apr 1, 2022
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Researchers at City of Hope, a world-renowned cancer research and treatment organization, have identified a pathway that explains how mutated cancer cells can continue to replicate and become resistant to oncology therapies.
Dec 2, 2021
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