Treating bacterial infections associated with orthopedic implants has often been a case of too little, too late. The traditional therapy has been a combination of prolonged antibiotics, including rifampin, a 50-year-old drug ...
Dec 16, 2021
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Although relatively rare in the United States, and accounting for fewer than 5 percent of tuberculosis cases worldwide, TB of the brain—or tuberculosis meningitis (TBM)—is often deadly, always hard to treat, and a particular ...
Dec 6, 2018
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Higher daily doses of rifampin, a cornerstone of tuberculosis treatment, killed more TB bacteria in sputum cultures, and the higher doses did so without increasing the adverse effects of treatment, according to a randomized ...
Jun 29, 2018
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Rutgers University scientists have determined the three-dimensional structure of the target of the first-line anti-tuberculosis drug rifampin. They have also discovered a new class of potential anti-tuberculosis drugs that ...
Apr 6, 2017
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Experts believe that tuberculosis, or TB, has been a scourge for humans for some 15,000 years, with the first medical documentation of the disease coming out of India around 1000 B.C.E. Today, the World Health Organization ...
Feb 24, 2020
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A Johns Hopkins Children's Center-led study in animals suggests that high doses of a widely used antibiotic called rifampin may safely treat and reduce the duration of treatment for the deadliest form of tuberculosis that ...
Mar 15, 2022
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(HealthDay)—For treatment of latent tuberculosis infection (LTBI), short-course rifamycin-based regimens are preferred over longer-course isoniazid monotherapy, according to guidelines published in the Feb. 14 issue of ...
Feb 14, 2020
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A 4-month rifampin regimen was found to be cheaper than a 9-month course of isoniazid for the treatment of latent tuberculosis in a cost-comparison study published in the Annals of Internal Medicine. Currently, isoniazid ...
Jun 16, 2020
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(HealthDay)—In pretreatment isolates of Mycobacterium tuberculosis, higher minimum inhibitory concentrations (MICs) of isoniazid and rifampin below the standard resistance breakpoint are associated with increased risk of ...
Aug 30, 2018
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Disease experts called Sunday for decisive leadership and more research funding to fend off the "very real" risk of an untreatable strain of tuberculosis (TB) emerging as more and more people develop resistance to existing ...
Mar 24, 2013
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