Oncology & Cancer
14-3-3sigma gene acts as a tumor suppressor in intestinal cancers
LMU researchers have identified the 14-3-3sigma gene as an important suppressor of carcinogenesis in the gastrointestinal tract.
Jun 16, 2021
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Page 21 - News tagged with signal pathways
Genetics
Study finds that regulatory protein prevents signaling that triggers cell death
A protein implicated in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) prevents the activation of an innate immune response that leads to cell death, Vanderbilt researchers have discovered.
May 7, 2021
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Diseases, Conditions, Syndromes
Scientists find a new anti-hepatic fibrosis drug target
Scientists from Russia and Italy studied a new axis of the pathway that prevents the development of liver fibrosis. The role of GILZ protein in curbing the disease progression was shown in a study using mice models and confirmed ...
May 4, 2021
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Medical research
Dietary amino acid determines the fate of cancer cells
A research group at the RIKEN Center for Biosystems Dynamics Research (BDR) has discovered molecular events that determine whether cancer cells live or die. With this knowledge, they found that reduced consumption of a specific ...
Apr 27, 2021
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Neuroscience
Two-color reporter shows cholinergic neurons engage ISR to modulate dopamine levels
A team of researchers from Duke University Medical Center, the California Institute of Technology, the National Institute of Mental Health and Baylor College of Medicine has found via a new reporter that cholinergic neurons ...
Medical research
Esophageal cancer: Discovery of the mechanisms involved
Metaplasia is defined as the replacement of a fully differentiated cell type by another. There are several classical examples of metaplasia, one of the most frequent is called Barrett's esophagus. Barrett's esophagus is characterized ...
Apr 21, 2021
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Oncology & Cancer
Scientists uncover mutations that make cancer resistant to therapies targeting KRAS
A gene called KRAS is one of the most commonly mutated genes in all human cancers, and targeted drugs that inhibit the protein expressed by mutated KRAS have shown promising results in clinical trials, with potential approvals ...
Apr 6, 2021
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Oncology & Cancer
Therapeutic resistance linked to softer tissue environment in breast cancer
Researchers at the University of California, San Francisco, have discovered that aggressive, triple-negative breast cancers (TNBCs) can evade treatment by reorganizing and softening the collagen matrix that surrounds the ...
Apr 2, 2021
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Medical research
The key to proper muscle growth
When a muscle grows, because its owner is still growing too or has started exercising regularly, some of the stem cells in this muscle develop into new muscle cells. The same thing happens when an injured muscle starts to ...
Feb 26, 2021
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Neuroscience
New signaling pathway in neurons
Neurodegenerative diseases, such as various forms of senile dementia or amyotrophic lateral sclerosis (ALS), have one thing in common: large amounts of certain RNA-protein complexes (snRNPs) are produced and deposited in ...
Feb 25, 2021
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