Oncology & Cancer
Fatal brake failures: Tumorigenesis in the colon
Two genes normally work together to suppress the development of colon cancer. Their combined loss favors tumorigenesis and stimulates the formation of metastases.
Dec 4, 2018
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Page 28 - News tagged with signal pathways
Genetics
Researchers discover why some parts of the body have hair and others don't
Why do humans have hair on our arms and legs but not on the palms of our hands and the soles of our feet? It's a fundamental question in human evolution that researchers at the Perelman School of Medicine at the University ...
Nov 28, 2018
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Medical research
Targeting a hunger hormone to treat obesity
About 64 per cent of Canadian adults are overweight or obese, according to Health Canada. That's a problem, because obesity promotes the emergence of chronic diseases such as type 2 diabetes, heart disease and some cancers.
Oct 22, 2018
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Medical research
New findings cast light on lymphatic system, key player in human health
Scientists at the Oklahoma Medical Research Foundation have broken new ground in understanding how the lymphatic system works, potentially opening the door for future therapies.
Oct 16, 2018
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Ophthalmology
Gene changes driving myopia reveal new focus for drug development
Myopia (nearsightedness) and hyperopia (farsightedness) develop through different molecular pathways, according to a new study publishing October 9 in the open-access journal PLOS Biology by Andrei Tkatchenko of Columbia ...
Oct 9, 2018
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Genetics
Researchers identify common molecular mechanism in two skeletal disorders
A rare and as-yet-unnamed skeletal disorder shares a common "signaling pathway" with another rare skeletal disorder called Jansen metaphyseal chondrodysplasia. (A signaling pathway is a group of molecules in a cell that work ...
Oct 9, 2018
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Oncology & Cancer
Optogenetic profiling used to identify alterations in Ras signaling dynamics within cancer cells
A team of researchers at the University of California has found that altering the signals that cells use to communicate with one another can cause changes to transcriptional outcomes, possibly resulting in the development ...
Diseases, Conditions, Syndromes
Study describes enzyme's key role in immune response to Chagas disease parasite
In an article published recently in the journal Nature Communications, researchers affiliated with the University of São Paulo (USP) in Brazil describe the central role played by an enzyme called phosphatidylinositol 3-kinase ...
Jul 16, 2018
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Neuroscience
Mind over matter: Amygdala circuit counteracts pain-driven emotion
Two pathways in the brain converging at the amygdala regulate the anxiety and depression that often accompanies chronic pain, suggests research in male rats published in JNeurosci. One of these pathways may represent a top-down ...
Jun 25, 2018
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Medical research
Signalling study sheds light on conditions from alopecia to cancer
Researchers from the University of Dundee and the Francis Crick Institute have made a significant discovery about a cellular pathway associated with developmental defects and a myriad of diseases ranging from alopecia to ...
Mar 22, 2018
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