Site 1 sodium channel blockers such as tetrodotoxin and saxitoxin are small-molecule drugs with powerful local anesthetic properties. They provide pain relief without toxic effects on local nerves and muscles, and are an ...
Sep 13, 2021
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Researchers from Case Western Reserve University have identified a potential new approach to better controlling epileptic seizures.
May 19, 2021
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Blood may seem like a simple fluid, but its chemistry is complex. When too much potassium, for instance, accumulates in the bloodstream, patients may experience deadly irregular heart rhythms.
May 4, 2021
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Muscle weakness in patients with Becker disease is caused by unusual electrical activity in muscle fibers termed 'plateau potentials' that make them temporarily inactive, says a study published today in eLife.
Apr 27, 2021
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In a development that may finally offer hope to children with Dravet syndrome and their parents, a promising investigational new therapeutic appears to alter the destructive course of the deadly disease in a mouse model.
Aug 26, 2020
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Ion channels, which allow potassium and sodium ions to flow in and out of cells, are crucial in neuronal 'firing' in the central nervous system and for brain and heart function. These channels use a "ball-and-chain" mechanism ...
Mar 18, 2020
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Roughly 80% of people with myotonic dystrophy—a common form of muscular dystrophy—experience dangerous heart ailments, and heart rhythm defects are the second-leading cause of death in those with the condition. In a new ...
Feb 27, 2020
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Seizure disorders in babies are frightening and heartbreaking. A new basic science breakthrough offers hope for a potential treatment for rare developmental and epileptic encephalopathies resulting from a single genetic mutation. ...
Feb 20, 2020
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Low oxygen levels in the heart have long been known to produce life-threatening arrhythmias, even sudden death. Until now, it was not clear how.
Feb 18, 2020
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Atomic-level studies of the architecture of tiny sodium channel proteins, critical to generating electrical signals that start off each beat of the heart, are imparting striking details about their function, malfunctions, ...
Dec 20, 2019
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