Casting one of the largest genomic nets to date for the rare tumors of the autonomic nervous system known as pheochromocytoma and paraganglioma (PCC/PGL) captured several new mutations driving the disease that could serve ...
Feb 13, 2017
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A new study provides some of the first links between relatively common mutations in the blood cells of elderly humans and atherosclerosis.
Jan 19, 2017
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A newly defined type of colorectal and endometrial cancer involves at least two somatic mutations in the mismatch repair genes (MMR): MLH1, MSH2, MSH6, PMS2. This double somatic MMR cancer has no germline mutations in the ...
Aug 16, 2016
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St. Jude Children's Research Hospital scientists have developed a web application and data set that gives researchers worldwide a powerful interactive tool to advance understanding of the mutations that lead to and fuel pediatric ...
Dec 29, 2015
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An eye-opening article from the International Cancer Genome Consortium (ICGC) was published today in the prestigious journal Nature Communications. It lays a foundation for the coming era of research in cancer genomics. The ...
Dec 9, 2015
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Every cell in the human body contains a copy of the human genome. Through the course of a lifetime all cells are thought to acquire mutations in their genomes. Some of the mutational processes generating these mutations do ...
Nov 9, 2015
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Walt Whitman's famous line, "I am large, I contain multitudes," has gained a new level of biological relevance.
Oct 1, 2015
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(Medical Xpress)—Perhaps the boldest attempt to date at a single unified explanation of cancer is that offered by Albert Szent-Gyorgi in his classic book, The Living State. That was over 40 years ago. His insights on the ...
A study that examined 17 million mutations in the genomes of 650 cancer patients concludes that large differences in mutation rates across the human genome are caused by the DNA repair machinery.
Feb 23, 2015
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A somatic mutation in the ATRX gene has recently been shown as a potential molecular marker for aggressive brain tumors, such as gliomas, neuroblastomas and pancreatic neuroendocrine tumors. Now, for the first time, researchers ...
Jan 21, 2015
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