Patients with metastatic pancreatic cancer who had germline or somatic mutations in DNA repair genes had better clinical outcomes after platinum-based chemotherapy, as compared with patients without these mutations, according ...
May 22, 2020
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For the first time, scientists are able to study changes in the DNA of any human tissue, following the resolution of long-standing technical challenges by scientists at the Wellcome Sanger Institute. The new method, called ...
Apr 28, 2021
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Researchers from the Spanish National Cancer Research Centre (CNIO) have discovered that more than 70% of bladder tumours display somatic mutations in the TERT gene (telomerase reverse transcriptase). The TERT gene is involved ...
Sep 10, 2013
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A new research paper titled "Genetic and therapeutic landscapes in cohort of pancreatic adenocarcinomas: next-generation sequencing and machine learning for full tumor exome analysis" has been published in Oncotarget.
Feb 14, 2024
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The cover for issue 5 of Oncotarget features Figure 2, "Survival curves in the KRAS, EGFR, and niche mutations cohorts," by Aramini, et al.
Feb 4, 2020
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Pathogenic gene mutations causing a type of intractable skin disease can be eliminated from some parts of patients' skin as they age, according to Hokkaido University researchers and their collaborators in Japan. This represents ...
Apr 1, 2019
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VEXAS syndrome is a severe autoinflammatory disease that results in a spectrum of rheumatologic and hematologic conditions. Mostly affecting men over age 50, VEXAS is caused by somatic mutations in the UBA1 gene of blood ...
Jul 10, 2023
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A team of researchers investigating the genome of a healthy supercentenarian since 2011 has found many somatic mutations – permanent changes in cells other than reproductive ones – that arose during the woman's lifetime. ...
Apr 30, 2014
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A new editorial paper titled "The uncharted role of HER2 mutant alleles in breast cancer has been published in Oncotarget.
Nov 6, 2023
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More than 1.4 million men were diagnosed with prostate cancer in 2020 globally, but the molecular characteristics of the disease remain unexplored for the majority of patients around the world. In the final days of the Movember ...
Nov 28, 2022
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