The therapeutic potential of human induced pluripotent stem cells (iPSCs), which are capable of becoming almost any type of cell in the human body, is well-recognized and broadly pursued, but their mutational burden has not ...
Jul 24, 2018
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40
A study of nearly 6,000 families, combining three genetic sequencing technologies, finds that mutations that occur after conception play an important role in autism. A team led by investigators at Boston Children's Hospital ...
Jul 17, 2017
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588
Gene mutations accumulating in cells are typical of the development of cancer. Finnish researchers have found that a similar accumulation of mutations occurs also in some patients with rheumatoid arthritis.
Jun 21, 2017
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167
A new study provides some of the first links between relatively common mutations in the blood cells of elderly humans and atherosclerosis.
Jan 19, 2017
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28
St. Jude Children's Research Hospital scientists have developed a web application and data set that gives researchers worldwide a powerful interactive tool to advance understanding of the mutations that lead to and fuel pediatric ...
Dec 29, 2015
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158
Every cell in the human body contains a copy of the human genome. Through the course of a lifetime all cells are thought to acquire mutations in their genomes. Some of the mutational processes generating these mutations do ...
Nov 9, 2015
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339
Walt Whitman's famous line, "I am large, I contain multitudes," has gained a new level of biological relevance.
Oct 1, 2015
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124
A study that examined 17 million mutations in the genomes of 650 cancer patients concludes that large differences in mutation rates across the human genome are caused by the DNA repair machinery.
Feb 23, 2015
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53
A somatic mutation in the ATRX gene has recently been shown as a potential molecular marker for aggressive brain tumors, such as gliomas, neuroblastomas and pancreatic neuroendocrine tumors. Now, for the first time, researchers ...
Jan 21, 2015
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45
DNA sequences were once thought to be identical from cell to cell, but it's increasingly understood that mutations can arise during brain development that affect only certain groups of brain cells. A technique developed at ...
Jan 7, 2015
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