Transcription factors (TFs) are proteins that bind to specific DNA sequences, regulating the transcription of genetic information from DNA to messenger RNA (mRNA). These proteins play a pivotal role in the regulation of gene ...
Researchers at Washington University School of Medicine in St. Louis have identified a process in immune cells that links vitamin D deficiency during pregnancy to an increased risk of type 2 diabetes in offspring. The researchers ...
Jun 13, 2023
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In the largest genetic study of bipolar disorder to date, researchers have identified 64 regions of the genome containing DNA variations that increase risk of bipolar disorder—more than double the number previously identified.
May 17, 2021
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While cancer therapies targeting specific genes or disease pathways can extend lives, they can also lead to highly resistant tumors when small reservoirs of cancer cells survive treatment, grow, and spread.
Mar 30, 2022
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Craniofacial birth defects, including cleft lip and palate, are among the most common human congenital malformations. Now, FMI researchers have identified a DNA region containing multiple regulatory elements that interact ...
Jun 6, 2023
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Swiss pharmaceuticals giant Novartis announced over the weekend it would dish out $9.7 billion (8.8 billion euros) to acquire US firm Medicines Company, in a move aimed at boosting its cardiovascular treatment portfolio.
Nov 25, 2019
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Researchers from the Smidt Heart Institute suggest that, contrary to common belief, the risk of developing high blood pressure has more to do with genetics in women than in men. The effect of genes on hypertension risk, when ...
Aug 31, 2021
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Mutations in the nuclear structural protein lamin A produce rare, tissue-specific diseases called laminopathies. To study these diseases, researchers from the Gasser group introduced a mutation inducing a human laminopathy ...
Mar 16, 2020
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Mount Sinai researchers have developed a new model that uses DNA and RNA sequencing data from hundreds of patients to identify specific genes and genetic alterations responsible for never-before-defined subtypes of a blood ...
Nov 17, 2021
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Scientists from Duke-NUS Medical School, in collaboration with counterparts from Columbia University, have developed a new framework to measure metabolic health. The concept of "metabolic elasticity" paints a more comprehensive ...
Nov 2, 2023
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