(HealthDay)—Metformin's role in atherosclerosis may be inhibition of monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation, according to research published online Dec. 31 in Diabetes.
Jan 9, 2015
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A Stony Brook University-led international team of infectious disease researchers have discovered how a cellular protein, called STAT3, which is overactive in a majority of human cancers, interferes with an antitumor mechanism ...
Mar 17, 2014
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When cancer spreads to another organ, it most commonly moves to the liver, and now researchers at the Abramson Cancer Center of the University of Pennsylvania say they know why. A new study, published today in Nature, shows ...
Mar 6, 2019
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Lying within our muscles are stem cells, invisible engines that drive the tissue's growth and repair. Understanding the signal(s) that direct muscle stem cells to spring into action could uncover new ways to promote muscle ...
Apr 17, 2019
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A successful interdisciplinary project is underway between two research groups, in which senior researcher Rebecka Hellsten and Professor Anders Bjartell at the Faculty of Medicine's division for Urological Cancer Research, ...
Aug 12, 2011
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For years, scientists have struggled to find a way to block a protein known to play an important role in many cancers. The protein, STAT3, acts as a transcription factor—it performs the crucial task of helping convert DNA ...
Nov 19, 2015
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The main cause of all forms of diabetes is pancreatic beta-cell dysfunction. Beta cells, found in the pancreatic islets, store and release insulin. Decades of research with animal and cellular models have expanded the knowledge ...
Sep 13, 2018
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Tumors usually grow exclusively from where their cell of origin derives. In humans, apart from some rare cases like the accidental transmission through a cut during surgery, there are no reports of contagious cancer cells. ...
Jan 14, 2019
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Researchers at Moffitt Cancer Center in Tampa, Fla., have discovered that the immune response regulator IKBKE (serine/threonine kinase) plays two roles in tobacco-related non-small cell lung cancers. Tobacco carcinogens induce ...
Feb 9, 2012
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Proper embryonic development depends on a signaling pathway that helps to preserve stem cell "immaturity."
Nov 6, 2013
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